| N2 and P3 components of event-related potential in first-episode schizophrenic patients: scalp topography, medication, and latency effects. | |
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MedLine Citation:
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PMID: 12374634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Auditory N2 and P3 components of event-related potentials were assessed in first-episode schizophrenic and normal control subjects (n=12/group). P3 amplitude was decreased in the patients most prominently over the frontal areas in contrast to a widespread P3 amplitude decrease reported in chronic schizophrenia. Moreover, frontal attenuation of P3 amplitude was greater in the non-medicated compared with medicated patients, a finding that suggests frontal areas are primarily affected at the onset of the first schizophrenic episode. Prolongation of N2 and P3 latencies was also observed in the patients, which indicates that stimulus classification and memory updating processes were slowed even in early stages of schizophrenia. These findings indicate that first-episode schizophrenic patients produce N2 and P3 abnormalities that are distinct from those in chronic patients, and that psychotropic medication can attenuate event-related potential effects in specific ways. |
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Authors:
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Tamer Demiralp; Alp Uçok; Müge Devrim; Ummühan Isoglu-Alkaç; Alper Tecer; John Polich |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Psychiatry research Volume: 111 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-10-10 Completed Date: 2003-04-07 Revised Date: 2008-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 167-79 Citation Subset: IM |
Affiliation:
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Department of Physiology, Istanbul University, Istanbul Medical Faculty, 34390 Capa-Istanbul, Turkey. demiralp@istanbul.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Adult Antipsychotic Agents / therapeutic use* Cerebral Cortex / drug effects, physiopathology* Electroencephalography* / drug effects Event-Related Potentials, P300 / drug effects, physiology* Evoked Potentials, Auditory / drug effects, physiology* Female Frontal Lobe / drug effects, physiopathology Humans Male Patient Admission Psychiatric Status Rating Scales Reaction Time / drug effects, physiology Schizophrenia / diagnosis*, drug therapy, physiopathology Schizophrenic Psychology* |
| Grant Support | |
ID/Acronym/Agency:
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R01-DA11737-04/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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