| N-terminal proatrial natriuretic factor. An independent predictor of long-term prognosis after myocardial infarction. | |
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MedLine Citation:
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PMID: 8181115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Atrial natriuretic factor (ANF) is a peptide hormone secreted from cardiac atria in response to increased atrial pressure. Because of a longer half-life and greater stability, the N-terminal of ANF prohormone (N-terminal proANF) may be a better integrator of atrial peptide secretion than ANF itself. After myocardial infarction, elevation of ANF and other neurohormones has been associated with a poor prognosis. However, when left ventricular ejection fraction (LVEF) and other important clinical variables are included in multivariate analysis, the independent predictive value of these neurohormones has been reduced markedly. METHODS AND RESULTS: To test the prognostic value of N-terminal proANF after myocardial infarction, its plasma concentration was measured a mean of 12 days after infarction in 246 patients in the Survival and Ventricular Enlargement (SAVE) Study. N-terminal proANF was a much stronger predictor of survival than ANF itself. Furthermore, in multivariate analysis of cardiovascular mortality and development of heart failure, N-terminal proANF in contrast to ANF and other neurohormones was still a powerful and independent predictor when the model included age, gender, prior myocardial infarction, hypertension, diabetes, use of thrombolysis, Killip class, infarct location, and LVEF. CONCLUSIONS: The measurement of N-terminal proANF supplements presently used clinical and objective assessments and provides an important independent predictor of prognosis with respect to cardiovascular mortality and development of heart failure. |
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Authors:
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C Hall; J L Rouleau; L Moyè; J de Champlain; D Bichet; M Klein; B Sussex; M Packer; J Rouleau; M O Arnold |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 89 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-06-14 Completed Date: 1994-06-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1934-42 Citation Subset: AIM; IM |
Affiliation:
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Institute for Surgical Research, University of Oslo, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Natriuretic Factor
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blood* Captopril / therapeutic use Female Follow-Up Studies Heart Failure / epidemiology Humans Male Middle Aged Multivariate Analysis Myocardial Infarction / blood, drug therapy, mortality* Peptide Fragments Predictive Value of Tests Prognosis Prospective Studies Protein Precursors / blood* Risk Factors Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/Protein Precursors; 114101-49-4/atrial natriuretic factor prohormone (1-98); 62571-86-2/Captopril; 85637-73-6/Atrial Natriuretic Factor |
| Comments/Corrections | |
Comment In:
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Circulation. 1995 Apr 15;91(8):2293-4
[PMID:
7697862
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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