Document Detail


N-terminal-proB-type natriuretic peptide predicts cardiovascular disease events in HIV-infected patients.
MedLine Citation:
PMID:  21245726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cardiovascular disease (CVD) is increasing in HIV-infected patients. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a significant predictor of CVD in the general population. We aimed to quantify the risk of CVD events associated with NT-proBNP at baseline in the Strategies for Management of Anti-Retroviral Therapy study.
METHODS: In a nested case-control study, NT-proBNP was measured at baseline in 186 patients who experienced a CVD event over an average of 2.8 years of follow-up and in 329 matched controls. Odds ratios (ORs) associated with baseline levels of NT-proBNP for CVD were estimated using conditional logistic regression.
RESULTS: At baseline median NT-proBNP [interquartile range (IQR)] was 48.1 (18.5, 112.9) pg/ml in patients who developed a CVD event and 25.7 (12.4, 50.2) pg/ml in controls. The unadjusted OR for the highest versus the lowest quartile was 3.7 [95% confidence interval (CI) 2.1-6.5, P < 0.0001]. After adjustment for baseline covariates and CVD risk factors, OR was 2.8 (95% CI 1.4-5.6, P = 0.003); with additional adjustment for IL-6, high-sensitivity C-reactive protein and D-dimer, OR was 2.3 (95% CI 1.1-4.9, P = 0.02).
CONCLUSIONS: Higher levels of NT-proBNP are associated with increased risk of CVD in HIV patients after considering established CVD risk factors and markers for inflammation and thrombosis.
Authors:
Daniel A Duprez; Jacqueline Neuhaus; Russell Tracy; Lewis H Kuller; Steven G Deeks; Chloe Orkin; Albrecht Stoehr; Ian J Woolley; James D Neaton;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  AIDS (London, England)     Volume:  25     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-03     Completed Date:  2011-07-07     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  651-7     Citation Subset:  IM; X    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00027352
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiovascular Diseases / complications,  metabolism*
Case-Control Studies
Creatine / metabolism*
Female
HIV Infections / complications,  metabolism*
HIV-1*
Humans
Male
Middle Aged
Natriuretic Peptide, Brain / metabolism*
Peptide Fragments / metabolism*
Predictive Value of Tests
Prognosis
Risk Assessment
Grant Support
ID/Acronym/Agency:
HL 090934-01/HL/NHLBI NIH HHS; MC_U122886352//Medical Research Council; R01 HL090934/HL/NHLBI NIH HHS; R01 HL090934-01/HL/NHLBI NIH HHS; U01AI042170/AI/NIAID NIH HHS; U01AI46362/AI/NIAID NIH HHS; UO1AI068641/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; MU72812GK0/Creatine
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