Document Detail


N-terminal pro-brain natriuretic peptide in the elderly with myocardial infarction.
MedLine Citation:
PMID:  18781605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The myocardial infarction (MI) results in the change of the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) in blood. In addition, attention is paid to the dependence of NT-proBNP levels on the patients' age. However, the behavior of natriuretic peptide levels has not been recognized well enough in the elderly with MI treated with invasive methods. HYPOTHESIS: The aim of the study was to estimate the effect of age on NT-proBNP levels in patients with first MI, and treated with primary percutaneous coronary intervention (PCI) with complete coronary revascularization. METHODS: One hundred and sixty-one consecutive patients with first ST-elevation MI, and treated with primary PCI with stent implantation (occlusion in infarct-related artery was the patient's only lession) were included. Determination of NT-proBNP level and echocardiography were performed on the 4th-5th day of MI. RESULTS: Thirty-seven patients (23%) aged>or=65 y were considered as a study group. The NT-proBNP levels were nearly 4-fold higher in older patients than in younger patients. Only systolic and diastolic dysfunction, mitral regurgitation, troponin T levels, and glomerular filtration rate (GFR) were independent risk factors of the occurrence of elevated NT-proBNP concentration above median. CONCLUSIONS: The patients' age was not a factor independently affecting the increase of NT-proBNP level above the median in patients with first MI and treated successfully with primary PCI. Independently associated elevated levels of NT-proBNP were as follows: presence of diastolic dysfunction, mitral regurgitation, left ventricular systolic dysfunction, troponin T concentration, and GFR.
Authors:
Iwona Szadkowska; Jan Henryk Goch; Janusz Kawiński; Krzysztof Chizyński
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical cardiology     Volume:  31     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  443-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 Wiley Periodicals, Inc.
Affiliation:
Invasive Cardiology Unit, Department of Cardiology, Medical University of Lodz, Lodz, Poland. iwonakoska@interia.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Angioplasty, Transluminal, Percutaneous Coronary
Female
Humans
Male
Middle Aged
Myocardial Infarction / blood*,  physiopathology,  therapy
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Stents
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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