Document Detail

N-terminal pro brain natriuretic peptide to predict prognosis in dilated cardiomyopathy with sinus rhythm.
MedLine Citation:
PMID:  17403613     Owner:  NLM     Status:  MEDLINE    
AIMS: To assess the value of plasma NT proBNP levels for predicting adverse outcomes in patients with dilated cardiomyopathy (DCM). METHODS: Seventy-eight patients with DCM (EF <40%) with sinus rhythm were enrolled. All patients had undergone echocardiographic examination, coronary angiography, and cardiac catheterisation. Blood samples for plasma NT proBNP levels were taken at rest following echocardiographic examination. Patients were followed up for 660+/-270 days for clinical endpoints defined as; death from worsening heart failure, sudden cardiac death and heart transplantation (Tx). RESULTS: Clinical end points were observed in 19 patients (5 Tx, 4 sudden cardiac death, 10 death from worsening heart failure). Variables associated with an increased hazard of clinical endpoints in univariate analysis were log NT proBNP, age, NYHA functional class, left ventricle ejection fraction, mitral valve effective regurgitation orifice area, and E wave deceleration time. The plasma level of NT proBNP (Hazard ratio=2.5 [95% CI: 1.3-4.7], p=0.0024) and age (hazard ratio=0.94 [95% CI: 0.90-0.98], p=0.0005) were the independent variables associated with an increased risk of clinical endpoints. NT proBNP plasma level >4500 pg/ml detected patients with clinical endpoints with a sensitivity, and specificity of 72%, 80%, respectively. The event free survival was found to be significantly lower in patients with NT proBNP levels >4500 pg/ml. CONCLUSION: NT proBNP seems to be a strong predictor of adverse outcomes in patients with DCM with sinus rhythm and may be used as a reliable biological marker in risk stratification.
Kursat Tigen; Tansu Karaahmet; Gokhan Kahveci; Ali Cevat Tanalp; Atilla Bitigen; Hakan Fotbolcu; Fatih Bayrak; Bulent Mutlu; Yelda Basaran
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Publication Detail:
Type:  Journal Article     Date:  2007-04-02
Journal Detail:
Title:  Heart, lung & circulation     Volume:  16     ISSN:  1443-9506     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-10-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  290-4     Citation Subset:  IM    
Kartal Kosuyolu Heart Education and Research Hospital, Department of Cardiology, Istanbul, Turkey.
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MeSH Terms
Analysis of Variance
Biological Markers / blood
Cardiomyopathy, Dilated / blood*,  complications,  diagnosis*,  physiopathology
Death, Sudden, Cardiac / etiology
Follow-Up Studies
Heart Conduction System / metabolism*,  physiopathology*,  ultrasonography
Heart Failure / etiology,  physiopathology
Middle Aged
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Proportional Hazards Models
Prospective Studies
Research Design
Sensitivity and Specificity
Stroke Volume
Survival Analysis
Ventricular Dysfunction, Left / etiology,  physiopathology
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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