Document Detail

N-terminal-pro-brain natriuretic peptide as a haemodynamic marker in idiopathic pulmonary arterial hypertension.
MedLine Citation:
PMID:  15738296     Owner:  NLM     Status:  MEDLINE    
Patients with idiopathic pulmonary arterial hypertension usually undergo acute vasodilator tests with nitric oxide (NO) for haemodynamic evaluation and therapeutical planning. The aim of this study was to evaluate the link between the variation of N-terminal (NT)-pro-brain natriuretic peptide (BNP) levels and haemodynamic parameters during the acute vasodilator test. A total of 22 idiopathic pulmonary arterial hypertension patients who underwent acute vasodilator tests were studied. Blood samples were collected at baseline and after 30 and 60 min of NO inhalation. NT-pro-BNP levels were measured in each sample. A receiver-operating characteristic curve was used to evaluate the capability of the NT-pro-BNP level variation during NO inhalation in recognising nonresponders. To distinguish responders from nonresponders, the increase of the NT-pro-BNP (0% as cut-off value) determined a 50% specificity and 100% sensitivity (positive predictive value of 38% and a negative predictive value of 100%). These results suggest that N-terminal-pro-brain natriuretic peptide was able to distinguish nonresponder patients with the acute vasodilator test. N-terminal-pro-brain natriuretic peptide may be an interesting additional biological tool in the evaluation of idiopathic pulmonary arterial hypertension patients.
R Souza; H B Bogossian; M Humbert; C Jardim; R Rabelo; M B P Amato; C R R Carvalho
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  25     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-01     Completed Date:  2005-07-12     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  509-13     Citation Subset:  IM    
Pulmonary Division, Pulmonary Hypertension Unit, Heart Institute University of São Paulo, Brazil.
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MeSH Terms
Biological Markers / blood
Bronchial Provocation Tests
Bronchodilator Agents / diagnostic use
Hemodynamics / drug effects
Hypertension, Pulmonary / blood*,  diagnosis*
Natriuretic Peptide, Brain
Nerve Tissue Proteins / blood*
Nitric Oxide / diagnostic use
Peptide Fragments / blood*
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 0/Bronchodilator Agents; 0/Nerve Tissue Proteins; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 10102-43-9/Nitric Oxide; 114471-18-0/Natriuretic Peptide, Brain

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