Document Detail

N-terminal pro-atrial natriuretic peptide response to acute exercise in depressed patients and healthy controls.
MedLine Citation:
PMID:  20950940     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acute exercise compared to healthy controls. Secondly, we aimed to assess the effect of antidepressants on NT-proANP response to acute exercise.
METHODS: We examined 132 outpatients with mild to moderate depression (ICD-10) and 44 healthy controls, group matched for age, sex, and BMI. We used an incremental bicycle ergometer test as a physical stressor. Blood samples were drawn at rest, at exhaustion, and 15, 30, and 60min post-exercise.
RESULTS: The NT-proANP response to physical exercise differed between depressed subjects and healthy controls (group×time; F(4,162.9)=10.92; p<0.001). The increase from rest to VO(2max) was 0.98 (SD 0.8) and 1.96nmol/l (SD 1.1), respectively, for depressed subjects and healthy controls (mean diff: 0.98nmol/l; 95% CI 0.7-1.3; t=6.63; df=170; p<0.001). The increase in NT-proANP from rest to peak VO(2max) was 1.27 (SD 1.0) and 0.84nmol/l (SD 0.6), respectively, for unmedicated and medicated patients (mean diff: 0.42nmol/l; 95% CI 0.1-0.8; t=2.56; df=128; p=0.01).
CONCLUSION: We observed an attenuated NT-proANP response to acute physical stress in depressed patients. Antidepressants were associated with an independent suppressive effect on the NT-proANP response.
Jesper Krogh; Andreas Ströhle; Asa Westrin; Tobias Klausen; Martin Balslev Jørgensen; Merete Nordentoft
Publication Detail:
Type:  Journal Article     Date:  2010-10-14
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  36     ISSN:  1873-3360     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  656-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Psychiatric Center Copenhagen, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
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