| N-terminal pro-BNP in sclerodermic patients on bosentan therapy for PAH. | |
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MedLine Citation:
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PMID: 18092166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic sclerosis (SSc) is characterized by vascular dysfunction that may lead to pulmonary artery hypertension (PAH). The N-terminal pro-B type natriuretic peptide (NT-proNBP), a marker of cardiac failure, is a diagnostic marker of early PAH in patients with SSc without heart failure. Our aim was to determine whether NT-proBNP levels may be a useful tool to evaluate the response to bosentan therapy in patients with PAH secondary to SSc. Ten patients with symptomatic, severe PAH secondary to SSc, received bosentan, 62.5 mg twice a day for 4 weeks followed by 125 mg twice a day for 7 months. Ten patients with SSc without PAH served as controls for basal level of NT-proBNP. Blood samples were obtained before the beginning of the therapy and after 3 and 7 months of treatment. SSc patients with PAH had significantly higher serum levels of NT-proBNP than those without PAH, at baseline. After 3 and 7 months of therapy, NT-proBNP concentration showed a progressive decrease, nearly approaching statistical difference at 7 months when compared to baseline levels (P=0.953 and P=0.600). Our results show that serum NT-proBNP levels may be a useful marker for the response to bosentan therapy in patients with PAH secondary to SSc. |
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Authors:
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Sara Simeoni; Giuseppe Lippi; Antonio Puccetti; Martina Montagnana; Elisa Tinazzi; Daniele Prati; Roberto Corrocher; Claudio Lunardi |
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Publication Detail:
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Type: Journal Article Date: 2007-12-19 |
Journal Detail:
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Title: Rheumatology international Volume: 28 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-08 Completed Date: 2008-07-24 Revised Date: 2013-06-18 |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 657-60 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Policlinico GB Rossi, P.le LA Scuro 37134, Verona, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Hypertension, Pulmonary / blood, drug therapy* Male Middle Aged Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Scleroderma, Systemic / blood, complications* Sulfonamides / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/Sulfonamides; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; Q326023R30/bosentan |
| Comments/Corrections | |
Comment In:
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Rheumatol Int. 2009 Jan;29(3):347-8
[PMID:
18690444
]
Rheumatol Int. 2008 Nov;29(1):115 [PMID: 18500454 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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