Document Detail


N-terminal parathyroid hormone-related protein levels in human intrauterine growth restricted pregnancies.
MedLine Citation:
PMID:  17653879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: N-terminal parathyroid hormone-related protein has a vital role in regulating cell growth and differentiation, uteroplacental vasodilatation, uterine muscle relaxation, and placental transport. These functions are compromised in intrauterine growth restriction. We aimed to investigate N-terminal parathyroid hormone-related protein concentrations in maternal, fetal, and neonatal plasma of intrauterine-growth-restricted and appropriate for gestational age pregnancies. METHODS: Plasma N-terminal parathyroid hormone-related protein levels were determined in 40 mothers and their 20 intrauterine-growth-restricted and 20 appropriate for gestational age singleton full-term fetuses and neonates on postnatal days 1 and 4. RESULTS: Fetal N-terminal parathyroid hormone-related protein levels were significantly lower in the intrauterine growth restriction group (b=1.166, 95%CI: 0.430-1.902, p=0.003) and correlated with the customized centiles of the infants (r=0.407, p=0.009). In the appropriate for gestational age group, neonatal day 1 N-terminal parathyroid hormone-related protein levels were significantly lower compared to maternal (p<0.001) and fetal (p=0.022) ones. Fetal and neonatal day 1 levels were significantly lower in males (b=-1.303, 95%CI: -2.508 to -0.097, p=0.036, and b=-0.802, 95%CI: -1.5 to -0.105, p=0.027, respectively). In the intrauterine growth restriction group, maternal N-terminal parathyroid hormone-related protein levels were significantly increased compared to fetal (p<0.001) and neonatal day 1 (p=0.001) levels. CONCLUSIONS: The reduced fetal N-terminal parathyroid hormone-related protein concentrations in intrauterine growth restriction may reflect compromised placental function and impaired fetal growth, suggesting that N-terminal parathyroid hormone-related protein may be involved in the pathogenesis of intrauterine growth restriction.
Authors:
Despina D Briana; Maria Boutsikou; Stavroula Baka; Demetrios Hassiakos; Demetrios Gourgiotis; Antonios Marmarinos; Nicoletta Iacovidou; Ariadne Malamitsi-Puchner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  86     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-26     Completed Date:  2007-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  945-9     Citation Subset:  IM    
Affiliation:
Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
Case-Control Studies
Female
Fetal Blood
Fetal Growth Retardation / blood,  metabolism*,  physiopathology
Fetus / metabolism
Gestational Age
Humans
Infant, Newborn
Male
Parathyroid Hormone-Related Protein / blood,  metabolism*
Pregnancy
Chemical
Reg. No./Substance:
0/Parathyroid Hormone-Related Protein

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