| N-terminal horseshoe conformation of DCC is functionally required for axon guidance and may be shared by other neural receptors. | |
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MedLine Citation:
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PMID: 23038776 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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DCC (Deleted in Colorectal Cancer) is a receptor for axon guidance cues netrin-1 and draxin. The interactions between these guidance cues and DCC play a key role in the development of the nervous system. Here, we present the crystal structure of the N-terminal four Ig-like domains of DCC. The molecule folds into a horseshoe-like configuration. We demonstrate that this horseshoe conformation of DCC is required for guidance cue mediated axonal attraction. Structure-based mutations that disrupt the DCC horseshoe indeed impair its function. A comparison of the DCC horseshoe with previously described horseshoe structures has revealed striking conserved structural features and important sequence signatures. Using these signatures a genome-wide search allows us to predict the N-terminal horseshoe arrangement in a number of other cell surface receptors, which nearly all function in the nervous system. The N-terminal horseshoe appears to be evolutionally selected as a platform for neural receptors. |
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Authors:
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Qiang Chen; Xiaqin Sun; Xiao-Hong Zhou; Jin-Huan Liu; Jane Wu; Yan Zhang; Jia-Huai Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-4 |
Journal Detail:
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Title: Journal of cell science Volume: - ISSN: 1477-9137 ISO Abbreviation: J. Cell. Sci. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0052457 Medline TA: J Cell Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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