Document Detail


N-terminal Prohormone B-type Natriuretic Peptide and Cardiovascular Function in Africans and Caucasians: The SAfrEIC Study.
MedLine Citation:
PMID:  22119736     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: This study compared NT-proBNP levels and the association with cardiovascular markers between Africans and Caucasians from South Africa. METHODS: This cross-sectional study involved 201 Africans and 255 Caucasians from the North West province, South Africa. Serum NT-proBNP concentrations, blood pressure, pulse wave velocity and arterial compliance were measured. RESULTS: NT-proBNP levels were significantly higher (P<0.001) in Africans than Caucasians, also after adjusting for gender, body mass index (BMI) and pulse wave velocity (P=0.008). This significant difference became borderline significant after adjusting for systolic blood pressure (SBP) (P=0.060), and non-significant after adjusting for arterial compliance (P=0.35). In single regression, a significant positive correlation of NT-proBNP with SBP (r=0.26; P<0.001) and pulse pressure (PP) (r=0.28; P<0.001) were shown for Africans only. After multiple adjustments, the associations of NT-proBNP with SBP and PP remained significant in Africans (SBP: β=0.187, P<0.01; PP: β=0.234, P<0.001), with no significant associations in Caucasians. CONCLUSIONS: NT-proBNP levels were higher in Africans than Caucasians, independently of BMI and gender. This difference was partly driven by higher SBP and lower arterial compliance in Africans. NT-proBNP was persistently associated with SBP and PP in Africans, but not in Caucasians. These associations may suggest early vascular changes contributing to cardiac alterations in Africans.
Authors:
Ruan Kruger; Rudolph Schutte; Hugo W Huisman; Peter Hindersson; Michael H Olsen; Aletta E Schutte
Related Documents :
21614456 - The impaired fibrinolytic capacity in hypertension is unaffected by acute blood pressur...
17523766 - Zofenopril versus lisinopril in the treatment of essential hypertension in elderly pati...
1783876 - Nitrendipine in treatment of hypertension.
2872806 - Comparative trials of terazosin with other antihypertensive agents.
20602106 - High-frequency percussive ventilation for airway clearance in cystic fibrosis: a brief ...
9591326 - Cardioprotective effects of beraprost sodium against experimental ischemia and reperfus...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-24
Journal Detail:
Title:  Heart, lung & circulation     Volume:  -     ISSN:  1444-2892     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.
Affiliation:
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Descriptive epidemiology of malignant mucosal and uveal melanomas and adnexal skin carcinomas in Eur...
Next Document:  Guidelines for the diagnosis and management of Catecholaminergic Polymorphic Ventricular Tachycardia...