| N-terminal Pro brain natriuretic peptide is a reliable biomarker of reduced myocardial contractility in patients with lamin A/C gene mutations. | |
| | |
MedLine Citation:
|
PMID: 20627339 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Recently, concerns have been raised about a possible lack of sensitivity of biomarkers to detect left ventricular (LV) dysfunction in patients with myopathies. We examined the ability of the N-terminal brain natriuretic peptide (NT-proBNP) to detect LV or right ventricular (RV) dysfunction in patients with lamin A/C (LMNA) gene mutations. METHODS: We prospectively measured plasma NT-proBNP in consecutive patients with documented LMNA mutations and age-sex matched controls. All patients underwent standard echocardiography implemented by pulsed tissue-Doppler echocardiography (TDE). RESULTS: Twenty-three patients were included (10 males, mean age 39.2±18.9years);10 had previous atrial arrhythmias, 8 had been implanted with cardioverter defibrillator for primary prevention of sudden death, 5 patients were of NYHA class II and 18 of NHYA class I. Sinus rhythm was recorded in all. NT-proBNP was increased in LMNA patients versus controls (123±229 versus 26±78pg/ml, p=0.0004); 7 patients had depressed LV and/or RV contractility. Patients with reduced LV or RV contractility had increased mean NT-proBNP (341±1032pg/ml versus 80±79pg/ml in patients with normal myocardial contractility, p=0.004). Receiver-operating-characteristics analysis shows that NT-proBNP reliably detected depressed contractility (area under the curve 0.889 [0.697-1.000]). Sensitivity and specificity were 88% and 83% respectively, applying manufacturer's recommended cut-off concentration of 125pg/ml. CONCLUSION: NT-proBNP reliably detected the presence of reduced LV/RV contractility in LMNA patients. |
| | |
Authors:
|
Christophe Meune; Karim Wahbi; Camille Gobeaux; Denis Duboc; Françoise Pecker; Gisèle Bonne |
Related Documents
:
|
15012919 - Diagnostic value of a rapid test for b-type natriuretic peptide in patients presenting ... 17383209 - Nt-probnp, igf-i and survival in patients with chronic heart failure. 16263579 - Elevated plasma levels of vascular endothelial growth factor is associated with marked ... 18199989 - Assessment of anthracycline-induced cardiotoxicity with biochemical markers. 1115509 - Intralesional triamcinolone therapy for pretibial myxedema. 19502379 - Relationship between renal function and serum cardiac troponin t in patients with chron... 2205929 - Unilateral spondylolysis associated with spina bifida occulta and nerve root compression. 3109229 - Efficacy and safety of flecainide acetate for atrial tachycardia or fibrillation. 19789539 - Licorice: a sweet alternative to prevent hyperkalemia in dialysis patients? |
Publication Detail:
|
Type: Journal Article Date: 2010-07-23 |
Journal Detail:
|
Title: International journal of cardiology Volume: 151 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-09-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 160-3 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Université Paris Descartes, Département de Cardiologie, Hôpital Cochin, AP-HP, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: On the nature of risk factors: A response to Kluttig, Kuss, and Greiser.
Next Document: Metabolic myopathy with noncompaction in an African.