Document Detail

N-phosphoryl amino acids and biomolecular origins.
MedLine Citation:
PMID:  15573496     Owner:  NLM     Status:  MEDLINE    
The possible role of phosphoryl amino acids for biomolecular origins is briefly reviewed. Peptide formation, ester formation, ester exchange on phosphorus and N to O migration occurred when the N-phosphoryl amino acid was incubated at room temperature. Short nucleotides and peptides were formed when nucleoside was reacted with N-phosphoryl amino acid at room temperature. Serine and threonine residues in their conjugate with different nucleosides (mediated with phosphorus) showed different self-cleavage activities. N-phosphoryl Histine and Ser-His dipeptide could cleave nucleic acids, proteins and esters in neutral medium. Based on a simple model, a pathway of 'co-evolution of protein and nucleic acid' was proposed.
C M Cheng; X H Liu; Y M Li; Y Ma; B Tan; R Wan; Y F Zhao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life     Volume:  34     ISSN:  0169-6149     ISO Abbreviation:  Orig Life Evol Biosph     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-12-02     Completed Date:  2005-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610391     Medline TA:  Orig Life Evol Biosph     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  455-64     Citation Subset:  IM; S    
The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, PR China.
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MeSH Terms
Amino Acids / chemistry*
Esters / chemistry*
Nucleosides / chemistry*
Nucleotides / chemistry*
Peptides / chemistry*
Reg. No./Substance:
0/Amino Acids; 0/Esters; 0/Nucleosides; 0/Nucleotides; 0/Peptides; 7723-14-0/Phosphorus

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