| N-phosphoryl amino acids and biomolecular origins. | |
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MedLine Citation:
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PMID: 15573496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The possible role of phosphoryl amino acids for biomolecular origins is briefly reviewed. Peptide formation, ester formation, ester exchange on phosphorus and N to O migration occurred when the N-phosphoryl amino acid was incubated at room temperature. Short nucleotides and peptides were formed when nucleoside was reacted with N-phosphoryl amino acid at room temperature. Serine and threonine residues in their conjugate with different nucleosides (mediated with phosphorus) showed different self-cleavage activities. N-phosphoryl Histine and Ser-His dipeptide could cleave nucleic acids, proteins and esters in neutral medium. Based on a simple model, a pathway of 'co-evolution of protein and nucleic acid' was proposed. |
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Authors:
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C M Cheng; X H Liu; Y M Li; Y Ma; B Tan; R Wan; Y F Zhao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life Volume: 34 ISSN: 0169-6149 ISO Abbreviation: Orig Life Evol Biosph Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-12-02 Completed Date: 2005-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610391 Medline TA: Orig Life Evol Biosph Country: Netherlands |
Other Details:
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Languages: eng Pagination: 455-64 Citation Subset: IM; S |
Affiliation:
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The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry* Biogenesis* Esters / chemistry* Nucleosides / chemistry* Nucleotides / chemistry* Peptides / chemistry* Phosphorus |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Esters; 0/Nucleosides; 0/Nucleotides; 0/Peptides; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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