| N omega-nitro-L-arginine, an inhibitor of nitric oxide synthesis, decreases noradrenaline outflow in rat isolated perfused mesenteric vasculature. | |
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MedLine Citation:
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PMID: 8474540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the isolated perfused rat mesenteric vasculature with intestine attached N omega-nitro-L-arginine (L-NNA) (30 mumol/l), an inhibitor of nitric oxide (NO) synthesis from L-arginine, did not alter spontaneous noradrenaline outflow. Transmural field stimulation (2-10 Hz) caused a frequency-dependent increase in noradrenaline outflow. The evoked overflow was reduced by L-NNA. L-Arginine (0.3 mmol/l) attenuated the inhibition of noradrenaline overflow by L-NNA. These results suggest that NO increases the release of noradrenaline in rat mesenteric vasculature. |
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Authors:
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R Yamamoto; A Wada; Y Asada; H Niina; A Sumiyoshi |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 347 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-05-20 Completed Date: 1993-05-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 238-40 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Miyazaki Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / analogs & derivatives*, pharmacology Atropine / pharmacology Electric Stimulation Guanethidine / pharmacology Intestines / blood supply, drug effects, physiology Male Mesenteric Arteries / drug effects*, metabolism*, secretion Nitric Oxide / metabolism* Nitroarginine Norepinephrine / metabolism*, secretion Perfusion Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 51-41-2/Norepinephrine; 51-55-8/Atropine; 55-65-2/Guanethidine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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