Document Detail


N omega-nitro-L-arginine and pulmonary vascular pressure-flow relationship in conscious dogs.
MedLine Citation:
PMID:  1590434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effects of an inhibitor of nitric oxide (NO) synthesis, N omega-nitro-L-arginine (L-NNA), on the pulmonary vascular pressure-flow relationship in chronically instrumented conscious dogs. The L-arginine analogue L-NNA (20 mg/min for 60 min iv) had no effect on the baseline pressure-flow relationship. This result indicates that tonic release of endothelium-derived relaxing factor (EDRF), which is thought to be NO or a labile NO-generating molecule, is not responsible for low resting pulmonary vasomotor tone in conscious dogs. In contrast, L-NNA caused a leftward shift in the dose-response relationship to the thromboxane mimetic U-46619, indicating that the endogenous release of EDRF modulates the pulmonary vascular response to this vasoconstrictor. Finally, after preconstriction with U-46619, L-NNA abolished the pulmonary vasodilator response to bradykinin (1-10 micrograms.kg-1.min-1) but had no effect on the pulmonary vasodilator response to sodium nitroprusside (1-10 micrograms.kg-1.min-1). Thus EDRF does not appear to tonically regulate the baseline pulmonary vascular pressure-flow relationship in conscious dogs. However, EDRF does act to attenuate the magnitude of U-46619-induced pulmonary vasoconstriction. Moreover, the pulmonary vasodilator response to bradykinin is entirely mediated by EDRF in conscious dogs.
Authors:
K Nishiwaki; D P Nyhan; P Rock; P M Desai; W P Peterson; C G Pribble; P A Murray
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  262     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-06-24     Completed Date:  1992-06-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1331-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
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MeSH Terms
Descriptor/Qualifier:
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Animals
Arginine / analogs & derivatives*,  pharmacology
Blood Pressure / drug effects*
Bradykinin / pharmacology
Dogs
Male
Nitroarginine
Nitroprusside / pharmacology
Prostaglandin Endoperoxides, Synthetic / pharmacology
Pulmonary Circulation / drug effects*
Vasoconstrictor Agents / pharmacology
Grant Support
ID/Acronym/Agency:
HL-02426/HL/NHLBI NIH HHS; HL-38291/HL/NHLBI NIH HHS; HL-40361/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Prostaglandin Endoperoxides, Synthetic; 0/Vasoconstrictor Agents; 15078-28-1/Nitroprusside; 2149-70-4/Nitroarginine; 58-82-2/Bradykinin; 74-79-3/Arginine; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

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