| N-methyl-D-aspartate stimulates dopamine release through nitric oxide formation in the nucleus accumbens of rats. | |
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MedLine Citation:
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PMID: 8616639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracerebral microdialysis technique was utilized to study the effect of NG-nitro-L-arginine, a nitric oxide (NO) synthase inhibitor, on N-methyl-D-aspartate (NMDA)-induced dopamine overflow in the nucleus accumbens of unanesthetized, freely moving rats. Perfusion of 1 and 3 mM NMDA through the microdialysis probe dose-dependently increased the extracellular dopamine level in the nucleus accumbens. Coapplication of 0.5 mM D-(-)-2-amino-5-phosphonovaleric acid (D-AP5), a selective and competitive NMDA receptor antagonist, significantly reduced the dopamine overflow induced by 3 mM NMDA. Perfusion of 0.5 mM NG-nitro-L-arginine alone did not affect the basal dopamine level, whereas it suppressed the NMDA-evoked dopamine overflow in the nucleus accumbens when concurrently applied with 3 mM NMDA. These results suggest that NO mediates, at least in part, dopamine release resulting from NMDA receptor activation in the nucleus accumbens of rats. |
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Authors:
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M Ohno; I Arai; S Watanabe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 699 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-06-12 Completed Date: 1996-06-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 332-5 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / pharmacology Dopamine / metabolism, secretion* Dose-Response Relationship, Drug Male N-Methylaspartate / pharmacology* Nitric Oxide / biosynthesis* Nucleus Accumbens / drug effects* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 6384-92-5/N-Methylaspartate; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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