| N-methyl-D-aspartate receptor-mediated increase in intracellular calcium is reduced by ketamine and phencyclidine. | |
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MedLine Citation:
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PMID: 2846317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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L-Glutamate, N-methyl-D-aspartate, quisqualate and potassium chloride enhanced Ca2+ accumulation by rat cortical slices as determined using 45Ca2+ uptake and Ca2+ mobilisation in cortical synaptosomes as determined using quin-2 fluorescence. Quinolinate and kainate were ineffective. Responses to L-glutamate and N-methyl-D-aspartate were blocked by non-competitive (ketamine, phencyclidine, Mg2+) and competitive (2-amino-5-phosphonovalerate) antagonists. These data suggest that activation of excitatory amino acid receptors in the cortex results in enhanced Ca2+ mobilisation which can be blocked by selective antagonists. Such effects may be related to neurotoxic properties of the excitatory amino acids and the neuroprotection afforded by excitatory amino acid antagonists. |
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Authors:
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C T O'Shaughnessy; D Lodge |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 153 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-12-21 Completed Date: 1988-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 201-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, Royal Veterinary College, London, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport, Active / drug effects Calcium / metabolism* Calcium Channels / drug effects, metabolism Cerebral Cortex / drug effects, metabolism Ketamine / pharmacology* Phencyclidine / pharmacology* Rats Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter / drug effects*, metabolism Synaptosomes / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 0/Receptors, N-Methyl-D-Aspartate; 0/Receptors, Neurotransmitter; 6740-88-1/Ketamine; 7440-70-2/Calcium; 77-10-1/Phencyclidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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