Document Detail

N-methyl-D-aspartate receptor-mediated increase in intracellular calcium is reduced by ketamine and phencyclidine.
MedLine Citation:
PMID:  2846317     Owner:  NLM     Status:  MEDLINE    
L-Glutamate, N-methyl-D-aspartate, quisqualate and potassium chloride enhanced Ca2+ accumulation by rat cortical slices as determined using 45Ca2+ uptake and Ca2+ mobilisation in cortical synaptosomes as determined using quin-2 fluorescence. Quinolinate and kainate were ineffective. Responses to L-glutamate and N-methyl-D-aspartate were blocked by non-competitive (ketamine, phencyclidine, Mg2+) and competitive (2-amino-5-phosphonovalerate) antagonists. These data suggest that activation of excitatory amino acid receptors in the cortex results in enhanced Ca2+ mobilisation which can be blocked by selective antagonists. Such effects may be related to neurotoxic properties of the excitatory amino acids and the neuroprotection afforded by excitatory amino acid antagonists.
C T O'Shaughnessy; D Lodge
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  153     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-12-21     Completed Date:  1988-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  201-9     Citation Subset:  IM    
Department of Physiology, Royal Veterinary College, London, U.K.
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MeSH Terms
Biological Transport, Active / drug effects
Calcium / metabolism*
Calcium Channels / drug effects,  metabolism
Cerebral Cortex / drug effects,  metabolism
Ketamine / pharmacology*
Phencyclidine / pharmacology*
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter / drug effects*,  metabolism
Synaptosomes / drug effects,  metabolism
Reg. No./Substance:
0/Calcium Channels; 0/Receptors, N-Methyl-D-Aspartate; 0/Receptors, Neurotransmitter; 6740-88-1/Ketamine; 7440-70-2/Calcium; 77-10-1/Phencyclidine

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