Document Detail


N-methyl-D-aspartate receptor-mediated increase in intracellular calcium is reduced by ketamine and phencyclidine.
MedLine Citation:
PMID:  2846317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
L-Glutamate, N-methyl-D-aspartate, quisqualate and potassium chloride enhanced Ca2+ accumulation by rat cortical slices as determined using 45Ca2+ uptake and Ca2+ mobilisation in cortical synaptosomes as determined using quin-2 fluorescence. Quinolinate and kainate were ineffective. Responses to L-glutamate and N-methyl-D-aspartate were blocked by non-competitive (ketamine, phencyclidine, Mg2+) and competitive (2-amino-5-phosphonovalerate) antagonists. These data suggest that activation of excitatory amino acid receptors in the cortex results in enhanced Ca2+ mobilisation which can be blocked by selective antagonists. Such effects may be related to neurotoxic properties of the excitatory amino acids and the neuroprotection afforded by excitatory amino acid antagonists.
Authors:
C T O'Shaughnessy; D Lodge
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  153     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-12-21     Completed Date:  1988-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  201-9     Citation Subset:  IM    
Affiliation:
Department of Physiology, Royal Veterinary College, London, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport, Active / drug effects
Calcium / metabolism*
Calcium Channels / drug effects,  metabolism
Cerebral Cortex / drug effects,  metabolism
Ketamine / pharmacology*
Phencyclidine / pharmacology*
Rats
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter / drug effects*,  metabolism
Synaptosomes / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Calcium Channels; 0/Receptors, N-Methyl-D-Aspartate; 0/Receptors, Neurotransmitter; 6740-88-1/Ketamine; 7440-70-2/Calcium; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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