| N-isopropyl-p-[123I]iodoamphetamine SPECT in MELAS syndrome: comparison with CT and MR imaging. | |
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MedLine Citation:
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PMID: 1987205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regional cerebral perfusion was studied in three patients with the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome, using single photon emission computed tomography (SPECT) with N-isopropyl-p-[123I]iodoamphetamine (IMP). Accumulation of the tracer was relatively decreased in the parietooccipital regions and also in the frontotemporal regions after stroke-like episodes. However, quantitative regional cerebral blood flow (rCBF) measurement showed that rCBF was relatively well preserved even at these sites, and a hyperemic state was observed at the sites of normal accumulation. IMP SPECT may be useful in the diagnosis and assessment of the progress of the MELAS syndrome. |
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Authors:
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M Satoh; N Ishikawa; T Yoshizawa; T Takeda; M Akisada |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 15 ISSN: 0363-8715 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 1991 Jan-Feb |
Date Detail:
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Created Date: 1991-02-15 Completed Date: 1991-02-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 77-82 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Tsukuba, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Lactic
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pathology,
radiography,
radionuclide imaging* Adolescent Adult Amphetamines / diagnostic use Brain Diseases / pathology, radiography, radionuclide imaging* Cerebrovascular Disorders / pathology, radiography, radionuclide imaging* Female Humans Iodine Radioisotopes / diagnostic use Iofetamine Magnetic Resonance Imaging Male Mitochondria, Muscle / radionuclide imaging Muscular Diseases / pathology, radiography, radionuclide imaging* Syndrome Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Amphetamines; 0/Iodine Radioisotopes; 95896-48-3/Iofetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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