| Nɛ-homocysteinyl-lysine isopeptide is associated with progression of peripheral artery disease in patients treated with folic acid. | |
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MedLine Citation:
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PMID: 22436266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Folic acid (FA) administration can reduce plasma total homocysteine (tHcy); however, it fails to decrease cardiovascular events and progression of peripheral artery disease (PAD). Nɛ-homocysteinyl-lysine isopeptide (Nɛ-Hcy-Lys) is formed during catabolism of homocysteinylated proteins. We sought to investigate factors that determine the presence of Nɛ-Hcy-Lys in PAD patients with hyperhomocysteinemia receiving FA. PATIENTS AND METHODS: We studied 131 consecutive PAD patients with tHcy > 15 μmol l(-1) taking FA 0.4 mg d(-1) for 12 months. Serum Nɛ-Hcy-Lys was determined by high-performance liquid chromatography (HPLC). We also measured interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA) and 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)). RESULTS: FA administration resulted in a 70.5% decrease in tHcy (p < 0.0001). However, serum Nɛ-Hcy-Lys was detectable in 28 (21.4%) patients on FA who were more frequently current smokers and survivors of ischaemic stroke (p < 0.001). They had higher tHcy by 46.0%, PAI-1 by 51.7%, 8-iso-PGF(2α) by 59.1% and ADMA by 26.4% (all, p < 0.0001). The presence of Nɛ-Hcy-Lys was associated with lower ankle-brachial index (ABI) values (p < 0.001) and higher prevalence of cardiovascular events (p < 0.001) following therapy. CONCLUSION: The presence of Nɛ-Hcy-Lys in one-fifth of hyperhomocysteinemic individuals with PAD despite FA treatment is associated with progression of PAD and with increased ADMA formation, oxidative stress and hypofibrinolysis. |
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Authors:
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P Mazur; A Kozynacka; L Durajski; R Głowacki; R Pfitzner; K Fijorek; J Sadowski; A Undas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-03-20 |
Journal Detail:
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Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: 43 ISSN: 1532-2165 ISO Abbreviation: Eur J Vasc Endovasc Surg Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-01 Completed Date: 2012-06-27 Revised Date: 2013-02-28 |
Medline Journal Info:
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Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: England |
Other Details:
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Languages: eng Pagination: 588-93 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Disease Progression Female Folic Acid / administration & dosage Homocysteine / blood, metabolism* Humans Hyperhomocysteinemia / blood, drug therapy, metabolism* Male Metabolism Middle Aged Oxidative Stress Peptides / blood, metabolism* Peripheral Arterial Disease / blood, metabolism, physiopathology* Proteins / metabolism* Vitamin B Complex / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 0/Proteins; 12001-76-2/Vitamin B Complex; 454-28-4/Homocysteine; 59-30-3/Folic Acid |
| Comments/Corrections | |
Comment In:
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Eur J Vasc Endovasc Surg. 2013 Feb;45(2):190-1
[PMID:
23305791
]
Eur J Vasc Endovasc Surg. 2013 Feb;45(2):190 [PMID: 23276678 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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