Document Detail


N-halo derivatives III: stabilization of nitrogen-chlorine bond in N-chloroamino acid derivatives.
MedLine Citation:
PMID:  1271254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The chlorination of alpha-amino acids and their related derivatives was investigated. A kinetic study of the stability of these N-chlorinated products led to an elucidation of the factors that significantly influence the stability and reactivity of the nitrogen-chlorine bond in these N-chloramines. From the kinetic investigations, a series of low chlorine potential, soft antimicrobial N-chloramines was developed based on derivatives of alpha-aminoisobutyric acid and related compounds.
Authors:
J J Kaminski; N Bodor; T Higuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  65     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  553-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids*
Buffers
Carboxylic Acids
Chemical Phenomena
Chemistry
Chloramines
Drug Stability
Kinetics
Sarcosine / analogs & derivatives
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Buffers; 0/Carboxylic Acids; 0/Chloramines; 107-97-1/Sarcosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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