| N-glycan based biomarker distinguishing non-alcoholic steatohepatitis from steatosis independently of fibrosis. | |
| | |
MedLine Citation:
|
PMID: 22119618 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Non-alcoholic fatty liver disease is a spectrum of disorders ranging from steatosis to non-alcoholic steatohepatitis (NASH). Steatosis of the liver is benign, whereas NASH can progress to cirrhosis or even hepatocellular carcinoma. Currently, a liver biopsy is the only validated method to distinct NASH from steatosis. AIM: The objective of this study was to identify a biomarker specific for NASH based on the N-glycosylation of serum proteins. METHODS: N-glycosylation patterns were assessed using DNA sequencer-assisted fluorophore-assisted capillary electrophoresis and compared with histology. RESULTS: Initially, a glycomarker (log[NGA2F]/[NA2]) was developed based on the results obtained in 51 obese non-alcoholic patients scheduled for bariatric surgery. Multivariate analysis showed that our glycomarker had the lowest P-value of all biomarkers in distinguishing NASH from steatosis (P=0.069). The glycomarker was validated in a cohort of 224 non-alcoholic fatty liver disease patients. In both pilot and validation study, glycomarker score increased in ascending amount of lobular inflammation (single-factor ANOVA, P≤0.001 and P=0.012, respectively). The N-glycan profile of immunoglobulin G in the NASH population confirmed the significantly increased undergalactosylation present in these patients. CONCLUSION: Our glycomarker specifically recognises liver inflammation in obese individuals which is the main trigger for the development of steatohepatitis and can differentiate between steatosis and NASH. |
| | |
Authors:
|
Bram Blomme; Sven Francque; Eric Trépo; Louis Libbrecht; Dieter Vanderschaeghe; An Verrijken; Piet Pattyn; Yves Van Nieuwenhove; Dirk Van De Putte; Anja Geerts; Isabelle Colle; Joris Delanghe; Christophe Moreno; Luc Van Gaal; Nico Callewaert; Hans Van Vlierberghe |
Related Documents
:
|
15051138 - Vestibular-evoked myogenic potentials in three patients with large vestibular aqueduct. 20948948 - The more the worse: the grade of noise-induced hearing loss associates with the severit... 19784408 - Results of air caloric and other vestibular tests in patients with chronic otitis media. 12621348 - Intralabyrinthine schwannomas. 8929828 - Blood lipids and rheological modifications in glycogen storage disease. 21277998 - The correlation between ventricular repolarization and clinical severity of spinal cord... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-24 |
Journal Detail:
|
Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: - ISSN: 1878-3562 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Safety and outcome of chemoradiotherapy in elderly patients with rectal cancer: Results from two Fre...
Next Document: Propofol, the preferred sedation for screening colonoscopy, is underused. Results of an internationa...