Document Detail


N-cadherin regulates mammary tumor cell migration through Akt3 suppression.
MedLine Citation:
PMID:  22410780     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-cadherin is a cell-cell adhesion molecule that plays a role in breast cancer metastasis. Here, we show that in vivo expression of N-cadherin in the PyMT mouse model, which enhances mammary tumor metastasis, results in selective inhibition of Akt3 expression and phosphorylation. Similarly, exogenous expression of N-cadherin in PyMT or MCF-7 mammary tumor cells enhanced cell motility and caused a dramatic reduction in Akt3 expression and phosphorylation. Moreover, knockdown of Akt3 in PyMT tumor cells increased cell motility and disrupted mammary morphogenesis, but had no effect on cell proliferation. Conversely, overexpression of wild-type Akt3 in PyMT-N-cadherin cells inhibited cell motility promoted by N-cadherin. Taken altogether, these findings demonstrate that N-cadherin suppresses Akt3 to promote cell motility and highlight the intricate regulation of Akt isoforms by N-cadherin during metastasis.
Authors:
S Chung; J Yao; K Suyama; S Bajaj; X Qian; O D Loudig; E A Eugenin; G R Phillips; R B Hazan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-03-12
Journal Detail:
Title:  Oncogene     Volume:  32     ISSN:  1476-5594     ISO Abbreviation:  Oncogene     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-24     Completed Date:  2013-06-04     Revised Date:  2014-02-26    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  422-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cadherins / genetics,  metabolism*
Cell Growth Processes / physiology
Cell Line
Cell Line, Tumor
Cell Movement / genetics,  physiology*
Female
HEK293 Cells
Humans
MCF-7 Cells
Mammary Neoplasms, Experimental / enzymology,  genetics,  metabolism*,  pathology*
Mice
Neoplasm Metastasis
Phosphorylation
Proto-Oncogene Proteins c-akt / antagonists & inhibitors*,  genetics,  metabolism*
Receptors, Fibroblast Growth Factor / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
1R01 CA135061-01A1/CA/NCI NIH HHS; R01 MH096625/MH/NIMH NIH HHS; T32 GM007491/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Cadherins; 0/Receptors, Fibroblast Growth Factor; EC 2.7.1.-/Akt3 protein, mouse; EC 2.7.11.1/Proto-Oncogene Proteins c-akt

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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