| N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma. | |
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MedLine Citation:
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PMID: 16258702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Upregulation of N-cadherin in epithelial tumor cells has been shown to contribute to the invasive/metastatic phenotype. It remains however to be determined whether N-cadherin is increased in human breast cancers with enhanced malignant potential. We examined a large number of invasive breast cancer specimens (n = 114) for N- and E-cadherin. These specimens compared invasive duct carcinomas (IDCs) of varying histologic grades with an aggressive subtype, invasive micropapillary carcinoma of the breast (MPAP), which has a high propensity for lymphatic invasion and lymph node metastasis. Staining scores for N- and E-cadherin were compared between non-MPAP and MPAP IDCs, and between the invasive and ductal carcinoma in situ (DCIS) of each IDC using statistical analysis. We found that N-cadherin was expressed in 76% of MPAP and 52% of non-MPAP carcinomas, and E-cadherin in 57% of MPAP and 36% of non-MPAP tumors. More MPAP (25%) compared to non-MPAP (5%) tumors expressed both cadherins. Of the two cadherins, N-cadherin was significantly associated with MPAP tumors (p = 0.033) compared to E-cad (p = 0.171). Moreover, in the majority of tumors that were positive for N-cadherin, the staining scores were increased in the IDC relative to intraductal components, and this effect was more dramatic in the MPAP carcinomas. This difference for N-cadherin was greater than the corresponding difference for E-cadherin in the MPAP group (p = 0.005), whereas such changes were not significant in the non-MPAP group (p = 0.10). Thus, N-cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression. |
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Authors:
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Chandandeep Nagi; Mitchell Guttman; Shabnam Jaffer; Rui Qiao; Rinat Keren; Aymara Triana; Maomi Li; James Godbold; Ira J Bleiweiss; Rachel B Hazan |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Breast cancer research and treatment Volume: 94 ISSN: 0167-6806 ISO Abbreviation: Breast Cancer Res. Treat. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-04-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8111104 Medline TA: Breast Cancer Res Treat Country: Netherlands |
Other Details:
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Languages: eng Pagination: 225-35 Citation Subset: IM |
Affiliation:
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Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD Breast Neoplasms / pathology* Cadherins / biosynthesis*, genetics Carcinoma, Ductal, Breast / pathology* Carcinoma, Papillary / pathology* Disease Progression Female Humans Lymphatic Metastasis Neoplasm Invasiveness* Phenotype Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
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5 R24 CA 88282-04/CA/NCI NIH HHS; R01 CA90872/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/CDH2 protein, human; 0/Cadherins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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