| N-brain natriuretic peptide: correlation with tricuspid insufficiency in Gaucher disease. | |
MedLine Citation:
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PMID: 15477128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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NT-pro-brain natriuretic peptide (NT-proBNP) values are correlated with right ventricle dysfunction in pulmonary hypertension and have been recommended as a prognostic marker for symptomatic primary pulmonary hypertension. The purpose of this pilot study was to determine whether NT-proBNP values correlate with mild to moderate pulmonary hypertension in Gaucher disease. The NT-proBNP assay was performed on sera from patients with type I (non-neuronopathic) Gaucher disease who were known to have tricuspid insufficiency (TI) gradient values on echocardiography that were normal (TI<20 mmHg), borderline (TI=25-29 mmHg), or abnormal (TI>or= 30 mmHg) over time. There was a statistically significant correlation (p=0.05) between mean NT-proBNP values and TI gradient group: mean NT-proBNP for normal TI gradient (n=20 patients)=133.3 (range: 46-445)pg/ml; mean NT-proBNP for borderline TI gradient (n=17 patients)=288.7 (range: 81-1088)pg/ml; and mean NT-proBNP for elevated TI gradient (n=10 patients)=1034.2 (73-6703)pg/ml. Treatment status was not correlated with TI gradient or NT-proBNP values. Thus, in this pilot study of Gaucher disease that included patients with mild to moderate pulmonary hypertension, NT-proBNP was correlated with echocardiographic findings. Further studies will be required to ascertain if NT-proBNP can be used for diagnosis and monitoring of these patients. |
Authors:
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Deborah Elstein; Amiram Nir; Mark Klutstein; Aya Abrahamov; Ari Zimran |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pulmonary pharmacology & therapeutics Volume: 17 ISSN: 1094-5539 ISO Abbreviation: Pulm Pharmacol Ther Publication Date: 2004 |
Date Detail:
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Created Date: 2004-10-12 Completed Date: 2005-03-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9715279 Medline TA: Pulm Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 319-23 Citation Subset: IM |
Affiliation:
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Gaucher Clinic, Shaare Zedek Medical Center, PO Box 3235, 91031 Jerusalem, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Biological Markers / blood Child Child, Preschool Cohort Studies Echocardiography Female Gaucher Disease / blood*, complications Humans Hypertension, Pulmonary / blood*, etiology Male Middle Aged Natriuretic Peptide, Brain / blood* Pilot Projects Prognosis Sensitivity and Specificity Severity of Illness Index Tricuspid Valve Insufficiency / blood*, etiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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