Document Detail


N-brain natriuretic peptide: correlation with tricuspid insufficiency in Gaucher disease.
MedLine Citation:
PMID:  15477128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
NT-pro-brain natriuretic peptide (NT-proBNP) values are correlated with right ventricle dysfunction in pulmonary hypertension and have been recommended as a prognostic marker for symptomatic primary pulmonary hypertension. The purpose of this pilot study was to determine whether NT-proBNP values correlate with mild to moderate pulmonary hypertension in Gaucher disease. The NT-proBNP assay was performed on sera from patients with type I (non-neuronopathic) Gaucher disease who were known to have tricuspid insufficiency (TI) gradient values on echocardiography that were normal (TI<20 mmHg), borderline (TI=25-29 mmHg), or abnormal (TI>or= 30 mmHg) over time. There was a statistically significant correlation (p=0.05) between mean NT-proBNP values and TI gradient group: mean NT-proBNP for normal TI gradient (n=20 patients)=133.3 (range: 46-445)pg/ml; mean NT-proBNP for borderline TI gradient (n=17 patients)=288.7 (range: 81-1088)pg/ml; and mean NT-proBNP for elevated TI gradient (n=10 patients)=1034.2 (73-6703)pg/ml. Treatment status was not correlated with TI gradient or NT-proBNP values. Thus, in this pilot study of Gaucher disease that included patients with mild to moderate pulmonary hypertension, NT-proBNP was correlated with echocardiographic findings. Further studies will be required to ascertain if NT-proBNP can be used for diagnosis and monitoring of these patients.
Authors:
Deborah Elstein; Amiram Nir; Mark Klutstein; Aya Abrahamov; Ari Zimran
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  17     ISSN:  1094-5539     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-12     Completed Date:  2005-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  319-23     Citation Subset:  IM    
Affiliation:
Gaucher Clinic, Shaare Zedek Medical Center, PO Box 3235, 91031 Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Biological Markers / blood
Child
Child, Preschool
Cohort Studies
Echocardiography
Female
Gaucher Disease / blood*,  complications
Humans
Hypertension, Pulmonary / blood*,  etiology
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Pilot Projects
Prognosis
Sensitivity and Specificity
Severity of Illness Index
Tricuspid Valve Insufficiency / blood*,  etiology
Chemical
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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