Document Detail


N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.
MedLine Citation:
PMID:  19041747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-acylphosphatidylethanolamines (NAPEs) are a relatively abundant group of plasma lipids of unknown physiological significance. Here, we show that NAPEs are secreted into circulation from the small intestine in response to ingested fat and that systemic administration of the most abundant circulating NAPE, at physiologic doses, decreases food intake in rats without causing conditioned taste aversion. Furthermore, (14)C-radiolabeled NAPE enters the brain and is particularly concentrated in the hypothalamus, and intracerebroventricular infusions of nanomolar amounts of NAPE reduce food intake, collectively suggesting that its effects may be mediated through direct interactions with the central nervous system. Finally, chronic NAPE infusion results in a reduction of both food intake and body weight, suggesting that NAPE and long-acting NAPE analogs may be novel therapeutic targets for the treatment of obesity.
Authors:
Matthew P Gillum; Dongyan Zhang; Xian-Man Zhang; Derek M Erion; Rachel A Jamison; Cheolsoo Choi; Jianying Dong; Marya Shanabrough; Hillary R Duenas; David W Frederick; Jennifer J Hsiao; Tamas L Horvath; Chun Min Lo; Pat Tso; Gary W Cline; Gerald I Shulman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  135     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2008-12-19     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  813-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Regulation*
Body Weight
Dietary Fats / metabolism
Endocannabinoids
Ethanolamines
Hypothalamus / metabolism
Intestine, Small / metabolism
Mice
Mice, Obese
Motor Activity
Obesity / metabolism
Palmitic Acids / metabolism
Phosphatidylethanolamines / blood,  physiology*
Proto-Oncogene Proteins c-fos / metabolism
Rats
Tandem Mass Spectrometry
Grant Support
ID/Acronym/Agency:
P30 DK-45735/DK/NIDDK NIH HHS; P30 DK045735-119001/DK/NIDDK NIH HHS; R01 DK-40936/DK/NIDDK NIH HHS; R01 DK040936-11/DK/NIDDK NIH HHS; R01 DK040936-23/DK/NIDDK NIH HHS; R01 DK049230-12/DK/NIDDK NIH HHS; R01 DK049230-13/DK/NIDDK NIH HHS; R24 DK085638/DK/NIDDK NIH HHS; R24 DK085638-02/DK/NIDDK NIH HHS; U24 DK-76169/DK/NIDDK NIH HHS; U24 DK059635/DK/NIDDK NIH HHS; U24 DK076169-03/DK/NIDDK NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Endocannabinoids; 0/Ethanolamines; 0/Palmitic Acids; 0/Phosphatidylethanolamines; 0/Proto-Oncogene Proteins c-fos; 544-31-0/palmidrol
Comments/Corrections

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