| N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake. | |
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MedLine Citation:
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PMID: 19041747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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N-acylphosphatidylethanolamines (NAPEs) are a relatively abundant group of plasma lipids of unknown physiological significance. Here, we show that NAPEs are secreted into circulation from the small intestine in response to ingested fat and that systemic administration of the most abundant circulating NAPE, at physiologic doses, decreases food intake in rats without causing conditioned taste aversion. Furthermore, (14)C-radiolabeled NAPE enters the brain and is particularly concentrated in the hypothalamus, and intracerebroventricular infusions of nanomolar amounts of NAPE reduce food intake, collectively suggesting that its effects may be mediated through direct interactions with the central nervous system. Finally, chronic NAPE infusion results in a reduction of both food intake and body weight, suggesting that NAPE and long-acting NAPE analogs may be novel therapeutic targets for the treatment of obesity. |
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Authors:
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Matthew P Gillum; Dongyan Zhang; Xian-Man Zhang; Derek M Erion; Rachel A Jamison; Cheolsoo Choi; Jianying Dong; Marya Shanabrough; Hillary R Duenas; David W Frederick; Jennifer J Hsiao; Tamas L Horvath; Chun Min Lo; Pat Tso; Gary W Cline; Gerald I Shulman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell Volume: 135 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-12-01 Completed Date: 2008-12-19 Revised Date: 2012-07-04 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 813-24 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Regulation* Body Weight Dietary Fats / metabolism Hypothalamus / metabolism Intestine, Small / metabolism Mice Mice, Obese Motor Activity Obesity / metabolism Palmitic Acids / metabolism Phosphatidylethanolamines / blood, physiology* Proto-Oncogene Proteins c-fos / metabolism Rats Tandem Mass Spectrometry |
| Grant Support | |
ID/Acronym/Agency:
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P30 DK-45735/DK/NIDDK NIH HHS; P30 DK045735-119001/DK/NIDDK NIH HHS; R01 DK-40936/DK/NIDDK NIH HHS; R01 DK040936-11/DK/NIDDK NIH HHS; R01 DK040936-23/DK/NIDDK NIH HHS; R01 DK049230-12/DK/NIDDK NIH HHS; R01 DK049230-13/DK/NIDDK NIH HHS; R24 DK085638/DK/NIDDK NIH HHS; R24 DK085638-02/DK/NIDDK NIH HHS; U24 DK-76169/DK/NIDDK NIH HHS; U24 DK076169-03/DK/NIDDK NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Palmitic Acids; 0/Phosphatidylethanolamines; 0/Proto-Oncogene Proteins c-fos; 544-31-0/palmidrol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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