Document Detail

N-acetylcysteine infusion reduces the resistance index of renal artery in the early stage of systemic sclerosis.
MedLine Citation:
PMID:  19730428     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate resistance index (RI) changes in renal artery after N-acetylcysteine infusion in patients with systemic sclerosis. METHODS: In an open-label study 40 patients with systemic sclerosis (SSc) were treated with N-acetylcysteine (NAC) iv infusion over 5 consecutive hours, at a dose of 0.015 g x kg(-1) x h(-1). Renal haemodynamic effects were evaluated by color Doppler examination before and after NAC infusion. RESULTS: NAC infusion significantly reduced RI in a group of sclerodermic patients with early/active capillaroscopic pattern, modified Rodnan Total Skin Score (mRTSS) <14 and mild-moderate score to the vascular domain of Medsger Scleroderma Disease Severity Scale (DSS). RI increased after NAC infusion in patients with late capillaroscopic pattern, mTRSS>14 and severe-end stage score to the vascular domain of DSS. In patients with reduction of RI after NAC infusion, diffusion capacity for carbon monoxide mean value was significantly higher than in those patients with an increase of RI. No significant differences in renal blood flow were found between patients with different subsets of SSc. CONCLUSION: In patients with low disease severity NAC ameliorates vascular renal function.
Edoardo Rosato; Rosario Cianci; Biagio Barbano; Ginevra Menghi; Antonietta Gigante; Carmelina Rossi; Enrico M Zardi; Antonio Amoroso; Simonetta Pisarri; Felice Salsano
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta pharmacologica Sinica     Volume:  30     ISSN:  1745-7254     ISO Abbreviation:  Acta Pharmacol. Sin.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-04     Completed Date:  2009-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956087     Medline TA:  Acta Pharmacol Sin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1283-8     Citation Subset:  IM    
Sapienza University of Rome Department of Clinical Medicine, Clinical Immunology Unit-Scleroderma Center, Italy.
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MeSH Terms
Acetylcysteine / therapeutic use*
Free Radical Scavengers / therapeutic use*
Microscopic Angioscopy
Middle Aged
Renal Artery / drug effects,  physiology
Renal Artery Obstruction / drug therapy*,  physiopathology
Scleroderma, Systemic / complications*,  physiopathology
Vascular Resistance / drug effects
Reg. No./Substance:
0/Free Radical Scavengers; 616-91-1/Acetylcysteine

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