Document Detail


N-acetylcysteine decreased nicotine self-administration and cue-induced reinstatement of nicotine seeking in rats: comparison with the effects of N-acetylcysteine on food responding and food seeking.
MedLine Citation:
PMID:  22903390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Chronic nicotine administration decreases the functioning of the cystine-glutamate antiporter system x(c)- which is hypothesized to promote nicotine-taking and nicotine-seeking behaviors. N-acetylcysteine (NAC), a cystine pro-drug, increases the activity of the cystine-glutamate antiporter system x(c)-. Thus, NAC could potentially reverse nicotine-induced alterations in glutamatergic transmission and decrease nicotine taking and seeking.
OBJECTIVES AND METHODS: To test this hypothesis in the present study, the effects of acute NAC treatment (30, 60, and 90 mg/kg, i.p.) on nicotine (fixed- and progressive-ratio schedules) and food (fixed-ratio schedule) self-administration were assessed in rats. In addition, the effects of acute NAC treatment on cue-induced reinstatement of nicotine- and food-seeking behaviors were investigated. Finally, the effects of repeated daily NAC administration (60 mg/kg, i.p., 14 days) on nicotine and food self-administration were assessed.
RESULTS: Acute NAC administration decreased nicotine self-administration but not food responding under a fixed-ratio schedule of reinforcement. In addition, acute NAC administration showed a nonsignificant trend in attenuating nicotine self-administration under a progressive-ratio schedule that was similar to the dose-response function under the fixed-ratio schedule. Furthermore, repeated NAC administration decreased nicotine self-administration from day 6 to 14 compared with vehicle treatment, with no indication of tolerance development. By contrast, repeated NAC administration decreased food responding from day 6 to 8 compared with vehicle treatment and showed rapid development of tolerance. Finally, acute NAC administration attenuated cue-induced reinstatement of nicotine and food seeking.
CONCLUSIONS: Altogether, these findings suggest that NAC may be useful in promoting smoking cessation in humans.
Authors:
Ana M Ramirez-Niño; Manoranjan S D'Souza; Athina Markou
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-08-19
Journal Detail:
Title:  Psychopharmacology     Volume:  225     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-06-10     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  473-82     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / administration & dosage,  pharmacology*
Animals
Conditioning, Operant / drug effects
Cues
Dose-Response Relationship, Drug
Eating / drug effects*
Feeding Behavior / drug effects*
Male
Nicotine / administration & dosage*
Rats
Rats, Wistar
Reinforcement Schedule
Self Administration
Grant Support
ID/Acronym/Agency:
DA11946/DA/NIDA NIH HHS; R01 DA011946/DA/NIDA NIH HHS; R56 DA011946/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
54-11-5/Nicotine; WYQ7N0BPYC/Acetylcysteine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacological effects of cannabinoids on the reference and working memory functions in mice.
Next Document:  Lurasidone in the treatment of schizophrenia: a 6-week, placebo-controlled study.