| N-acetyl-transferase phenotype and risk for preeclampsia. | |
| | |
MedLine Citation:
|
PMID: 16150277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: This study was undertaken to determine whether the N-acetyltransferase (NAT) phenotype contributes to the susceptibility for the development of preeclampsia. STUDY DESIGN: The NAT acetylator status was determined by measuring urinary caffeine metabolites in 134 nonpregnant women with a history of preeclampsia and in 109 control women with uncomplicated pregnancy. The chi(2) and logistic regression analyses were used for statistical evaluation of differences in acetylator status. RESULTS: Significantly more fast acetylators were found among the women with a history of preeclampsia (46.3%) than among the controls (25.4%). Fast acetylators showed an odds ratio of 2.5 (95% CI 1.4-4.3) for preeclampsia. No differences in the acetylator status were found between women with a history of preeclampsia only and those with the HELLP syndrome as well. CONCLUSION: The fast NAT acetylator status, which may result in altered NAT detoxification capacity, is associated with preeclampsia. |
| | |
Authors:
|
Petra L M Zusterzeel; René H M te Morsche; Maarten T M Raijmakers; Eva Maria Roes; Wilbert H M Peters; Régine P M Steegers-Theunissen; Eric A P Steegers |
Related Documents
:
|
21289937 - Hormones for therapy of climacteric afflictions. 19930427 - Role of proteinuria in defining pre-eclampsia: clinical outcomes for women and babies. 12800207 - Childhood exposure to simian virus 40-contaminated poliovirus vaccine and risk of aids-... 10640157 - A prospective study of pregravid oral contraceptive use and risk of hypertensive disord... 20080847 - Impact of growth hormone therapy on quality of life in adults with turner syndrome. 19754927 - Hemoglobin levels and anemia evaluation during pregnancy in the highlands of tibet: a h... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 193 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Sep |
Date Detail:
|
Created Date: 2005-09-09 Completed Date: 2005-10-21 Revised Date: 2010-09-08 |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 797-802 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arylamine N-Acetyltransferase / genetics* Caffeine / metabolism, urine Female Genetic Predisposition to Disease HELLP Syndrome / genetics Humans Phenotype Pre-Eclampsia / genetics* Pregnancy Smoking / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
|
58-08-2/Caffeine; EC 2.3.1.5/Arylamine N-Acetyltransferase; EC 2.3.1.5/NAT2 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Misoprostol induces cervical nitric oxide release in pregnant, but not in nonpregnant, women.
Next Document: Profound hypotension and associated electrocardiographic changes during prolonged cord occlusion in ...