Document Detail

N-acetyl cysteine for treatment of recurrent unexplained pregnancy loss.
MedLine Citation:
PMID:  18983759     Owner:  NLM     Status:  MEDLINE    
Pregnancy could be associated with a state of oxidative stress that could initiate and propagate a cascade of changes that may lead to pregnancy wastage. This process of oxidative stress may be suppressed by the antioxidant effect of N-acetyl cysteine (NAC). The current study aimed to evaluate the effect of NAC therapy in patients diagnosed with unexplained recurrent pregnancy loss (RPL). The study was a prospective controlled study performed in the Women's Health Centre, Assiut University, Egypt. A group of 80 patients with history of recurrent unexplained pregnancy loss were treated with NAC 0.6 g + folic acid 500 microg/day and compared with an aged-matched group of 86 patients treated with folic acid 500 microg/day alone. NAC + folic acid compared with folic acid alone caused a significantly increased rate of continuation of a living pregnancy up to and beyond 20 weeks [P < 0.002, relative risk (RR) 2.9, 95% confidence interval (CI) 1.5-5.6]. NAC + folic acid was associated with a significant increase in the take-home baby rate as compared with folic acid alone (P < 0.047, RR 1.98, 95% CI 1.3-4.0). In conclusion, NAC is a well-tolerated drug that could be a potentially effective treatment in patients with unexplained RPL.
Ahmed F Amin; Omar M Shaaban; Mohamed A Bediawy
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  17     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  722-6     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Women's Health Centre, Faculty of Medicine, Assiut University, Assiut, Egypt.
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MeSH Terms
Abortion, Habitual / drug therapy*,  etiology,  metabolism
Acetylcysteine / therapeutic use*
Antioxidants / therapeutic use*
Infant, Newborn
Oxidative Stress / drug effects
Pregnancy Outcome
Prospective Studies
Young Adult
Reg. No./Substance:
0/Antioxidants; 616-91-1/Acetylcysteine

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