Document Detail


N-Acetyl-cysteine against noise-induced temporary threshold shift in male workers.
MedLine Citation:
PMID:  20638463     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous animal studies showed protective effects of antioxidant medicines against noise-induced hearing loss (NIHL). It is unclear whether antioxidants would protect humans from NIHL. We conducted a study to determine whether N-Acetyl-cysteine (NAC) protected men against noise-induced temporary threshold shift (TTS), and whether subgroups with genetic polymorphisms of glutathione S-transferase (GST) T1 and M1 responded to NAC differently. In this prospective, double-blind, crossover study, 53 male workers were randomly assigned to receive either NAC (1200 mg/day, 14 days) during the first period and placebo during the second period, or placebo during the first period and NAC during the second period. Dosing periods were separated by a washout period of 2 weeks. The hearing threshold changes were determined before and after each dosing period. Pre-shift hearing threshold for high frequencies was 19.1 dB. Daily exposure to noise ranged from 88.4 to 89.4 dB. The noise levels of different frequencies ranged from 80.0 to 89.4 dB with a peak-value at 4 kHz. NAC significantly reduced TTS (p = 0.03). When the participants were grouped by GST M1/T1 genotypes, the NAC effect was only significant among workers with null genotypes in both GSTM1 and GSTT1 (p = 0.004). NAC may prevent noise-induced TTS among occupationally noise-exposed men. The protective effect of NAC was more prominent in subjects with both GSTM1-null and GSTT1-null genotypes. (clinicaltrials.gov Identifier: NCT00552786).
Authors:
Cheng-Yu Lin; Jiunn-Liang Wu; Tung-Sheng Shih; Perng-Jy Tsai; Yih-Min Sun; Mi-Chia Ma; Yueliang L Guo
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-07-16
Journal Detail:
Title:  Hearing research     Volume:  269     ISSN:  1878-5891     ISO Abbreviation:  Hear. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  42-7     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Tainan Hospital, Department of Health, West Central District, Tainan City 700, Taiwan.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00552786
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / administration & dosage,  pharmacology,  therapeutic use*
Administration, Oral
Adult
Auditory Threshold* / drug effects
Cross-Over Studies
Double-Blind Method
Free Radical Scavengers / administration & dosage,  pharmacology,  therapeutic use*
Genotype
Glutathione Transferase / genetics
Hearing Loss, Noise-Induced / prevention & control*
Humans
Male
Middle Aged
Noise, Occupational / adverse effects*
Polymorphism, Genetic / genetics
Prospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Free Radical Scavengers; 616-91-1/Acetylcysteine; EC 2.5.1.-/glutathione S-transferase T1; EC 2.5.1.18/Glutathione Transferase; EC 2.5.1.18/glutathione S-transferase M1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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