Document Detail


N-acetyl-4-aminophenol and musculoskeletal adaptations to resistance exercise training.
MedLine Citation:
PMID:  23108581     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-acetyl-4-aminophenol (ACET) may impair musculoskeletal adaptations to progressive resistance exercise training (PRT) by inhibiting exercise-induced muscle protein synthesis and bone formation. To test the hypothesis that ACET would diminish training-induced increases in fat-free mass (FFM) and osteogenesis, untrained men (n = 26) aged ≥50 years participated in 16 weeks of high-intensity PRT and bone-loading exercises and were randomly assigned to take ACET (1,000 mg/day) or placebo (PLAC) 2 h before each exercise session. Total body FFM was measured by DXA at baseline and week 16. Serum bone-specific alkaline phosphatase (BAP) and C-terminal crosslinks of type-I collagen (CTX) were measured at baseline and week 16. Vastus lateralis muscle biopsies were performed at baseline and weeks 3 and 16 for prostanoid, anabolic, and catabolic gene expression by RT-PCR. In exercise-compliant men (ACET, n = 10; PLAC, n = 7), the increase in FFM was not different between groups (p = 0.91). The changes in serum BAP and CTX were not different between groups (p > 0.7). There were no significant changes in any of the target genes at week 3. After 16 weeks of PRT, the mRNA expressions of the anabolic marker p70S6K (p = 0.003) and catabolic marker muscle-atrophy F-box (MAFbx) (p = 0.03) were significantly reduced as compared to baseline in ACET. The mRNA expression of the prostanoids were unchanged (all p ≥ 0.40) in both groups. The administration of ACET (1,000 mg) prior to each exercise session did not impair PRT-induced increases in FFM or significantly alter bone formation markers in middle aged and older men.
Authors:
Catherine M Jankowski; Wendolyn S Gozansky; Paul S MacLean; Benjamin Shulman; Pamela Wolfe; Robert S Schwartz; Wendy M Kohrt
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-30
Journal Detail:
Title:  European journal of applied physiology     Volume:  113     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-12     Completed Date:  2013-09-30     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1127-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / pharmacology*
Adaptation, Physiological*
Alkaline Phosphatase / blood
Bone and Bones / drug effects*,  metabolism,  physiology
Case-Control Studies
Collagen Type I / blood
Exercise*
Humans
Male
Middle Aged
Muscle, Skeletal / drug effects*,  metabolism,  physiology
Osteogenesis / drug effects
Peptides / blood
Resistance Training*
Transcription, Genetic / drug effects
Grant Support
ID/Acronym/Agency:
P30 DK048520/DK/NIDDK NIH HHS; R01 AG018857/AG/NIA NIH HHS; R21 AG027809/AG/NIA NIH HHS; R21 AG027809/AG/NIA NIH HHS; UL1 TR000154/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Collagen Type I; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 362O9ITL9D/Acetaminophen; EC 3.1.3.1/Alkaline Phosphatase
Comments/Corrections

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