Document Detail


N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Severity of the Coronary Lesions in Unstable Angina Patients with Preserved Left Ventricular Function.
MedLine Citation:
PMID:  22150844     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives:  To evaluate the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) values and the severity of coronary lesions at angiography in unstable angina patients with preserved left ventricular function. Methods:  A total of 133 patients with primary diagnosis of unstable angina were enrolled into this study. NT-proBNP level was determined before the angiography and Gensini score, a measurement of extent of myocardial ischemia, was calculated after the angiography by experienced cardiologists. Patients with >50% stenosis of the left main or 75% stenosis of one or more coronary branches with diameter >2 mm were defined as "angiography positive" and turned to percutaneous coronary intervention. Results:  There was a significant difference of circulating NT-proBNP level between the angiography positive and negative groups and the median NT-proBNP values were 367.5 pg/mL and 112 pg/mL, respectively (P < 0.001). A significant correlation was observed between log NT-proBNP and log Gensini score (P < 0.001). NT-proBNP level was a predictor of angiography positive result and the area under the receiver operating characteristic curve was 0.776 (95% CI 0.693-0.858). Conclusions:  NT-proBNP level was found to be higher with the severity of myocardial ischemia. However, the ability of NT-proBNP to identify clinically significant angiographic lesions was moderate. (J Interven Cardiol 2011;**:1-6).
Authors:
Gao Wei; Wang Ningfu; Ye Xianhua; Zhou Liang; Yang Jianmin; Tong Guoxin; Xu Peng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-12
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  -     ISSN:  1540-8183     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2011, Wiley Periodicals, Inc.
Affiliation:
Department of Cardiology, Hangzhou No. 1 Municipal Hospital and Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou, China.
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