| N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Severity of the Coronary Lesions in Unstable Angina Patients with Preserved Left Ventricular Function. | |
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MedLine Citation:
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PMID: 22150844 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: To evaluate the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) values and the severity of coronary lesions at angiography in unstable angina patients with preserved left ventricular function. Methods: A total of 133 patients with primary diagnosis of unstable angina were enrolled into this study. NT-proBNP level was determined before the angiography and Gensini score, a measurement of extent of myocardial ischemia, was calculated after the angiography by experienced cardiologists. Patients with >50% stenosis of the left main or 75% stenosis of one or more coronary branches with diameter >2 mm were defined as "angiography positive" and turned to percutaneous coronary intervention. Results: There was a significant difference of circulating NT-proBNP level between the angiography positive and negative groups and the median NT-proBNP values were 367.5 pg/mL and 112 pg/mL, respectively (P < 0.001). A significant correlation was observed between log NT-proBNP and log Gensini score (P < 0.001). NT-proBNP level was a predictor of angiography positive result and the area under the receiver operating characteristic curve was 0.776 (95% CI 0.693-0.858). Conclusions: NT-proBNP level was found to be higher with the severity of myocardial ischemia. However, the ability of NT-proBNP to identify clinically significant angiographic lesions was moderate. (J Interven Cardiol 2011;**:1-6). |
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Authors:
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Gao Wei; Wang Ningfu; Ye Xianhua; Zhou Liang; Yang Jianmin; Tong Guoxin; Xu Peng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
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Title: Journal of interventional cardiology Volume: - ISSN: 1540-8183 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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©2011, Wiley Periodicals, Inc. |
Affiliation:
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Department of Cardiology, Hangzhou No. 1 Municipal Hospital and Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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