| N-Substituted-2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives as anti-tumor agents against Ehrlich ascites tumor cells in vivo. | |
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MedLine Citation:
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PMID: 17504198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives were synthesized by using the different bioactive heteroaralkyl halides with 2-butyl-4-chloro-1H-imidazole-5-carbaldehyde in presence of powdered potassium carbonate in DMF medium. These compounds were screened for their antitumor activity. Our results show that treatment of imidazole derivatives inhibit proliferation EAT cells, decreases the ascites volume and increases the survivability of the animals in vivo. These compounds also inhibited the cellular proliferation of HUVEC cells in vitro by MTT assay. Further, these compounds could induce apoptosis, which is evident by the nuclear condensation of imidazole derivatives treated EAT cells in vivo by the cytological analysis. We have identified that pyrrolidine substituted imidazole derivative as potent anti-tumor compound. These inhibitors could represent as promising candidates for anticancer therapies, where the formation of peritoneal malignant ascites is a major cause of morbidity and mortality. |
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Authors:
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C Anil Kumar; S Nanjunda Swamy; S L Gaonkar; Basappa; Bharathi P Salimath; Kanchugarakoppal S Rangappa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicinal chemistry (Shāriqah (United Arab Emirates)) Volume: 3 ISSN: 1573-4064 ISO Abbreviation: - Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-16 Completed Date: 2007-07-25 Revised Date: 2008-02-26 |
Medline Journal Info:
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Nlm Unique ID: 101240303 Medline TA: Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 269-76 Citation Subset: IM |
Affiliation:
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Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysore, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes
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chemistry,
pharmacology* Animals Antineoplastic Agents / chemical synthesis, chemistry* Apoptosis / drug effects Carcinoma, Ehrlich Tumor / drug therapy* Cell Line, Tumor Cell Proliferation / drug effects Drug Screening Assays, Antitumor Humans Imidazoles / chemistry, pharmacology* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Antineoplastic Agents; 0/Imidazoles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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