Document Detail

N-SIPPV vs Bi-Level N-CPAP for early treatment of Respiratory Distress Syndrome in Preterm Infants.
MedLine Citation:
PMID:  23488612     Owner:  NLM     Status:  Publisher    
Abstract Objective: Non-invasive ventilation (NIV) for RDS in extremely/very low birth-weight infants, represents the new challenge for neonatologists. In this regard, data comparing the effectiveness of BiLevel-NCPAP (BiPAP) versus Nasal Synchronized Intermittent Positive Pressure Ventilation (NSIPPV) as primary mode of treatment for RDS are lacking. Study design: We conducted a retrospective study from December 2007 to December 2010 in seventyeight infants, who received NIV (N-SIPPV: 33; BiPAP: 45). The primary outcomes were the length and failure of NIV. Secondary outcomes were: adverse short-long term pulmonary outcomes, multiple doses of surfactant and others. Results: There were no significant differences (P>0.05) between the two different NIV modes. Conclusion: The present findings suggest that N-SIPPV and BiPAP gives similar results in the RDS treatment. We did not find a benefit of one over the other ventilation mode and both could be constitute a valid option to conventional mechanical ventilation. The theoretical benefits of these two different methods of NIV are: tidal volume enhancement, improvements of the functional residual capacity and of the mean airway pressure and reducing apnea episodes. Further randomized studies to assess the advantages and the efficacy of different methods of NIV for the treatment of the RDS are needed.
Alberto Ricotti; Vincenzo Salvo; Luc Ji Zimmermann; Antonio Wd Gavilanes; Ignazio Barberi; Gianluca Lista; Micaela Colivicchi; Francesca Temporini; Diego Gazzolo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-14
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Neonatal Intensive Care Unit, C. Arrigo Children's Hospital, Alessandria, Italy.
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