| N-Phthaloyl gamma-aminobutyric acid affects biochemical circadian rhythms in Wistar rats. | |
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MedLine Citation:
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PMID: 11491582 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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N-Phthaloyl gamma-aminobutyric acid (P-GABA) was administered to Wistar rats and 24 hr rhythms of glucose, cholesterol, total protein and lactic acid levels in blood were studied under semi-natural light dark conditions. P-GABA administration caused desynchronisation of the rhythms; while glucose and lactic acid rhythms were advanced, cholesterol and total protein rhythms were delayed. Since GABA is being involved in conveying dark information to the clock, exogenous administration of P-GABA may reduce the photic information received by the clock. The results could be explained by slightly less than 1 hr daily delays (or) advances respectively which would bring the peak times to the points 21 days after the start of administration. |
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Authors:
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P Subramanian; S Sundaresan; E Balamurugan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 39 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-08-08 Completed Date: 2001-09-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: India |
Other Details:
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Languages: eng Pagination: 360-4 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Science, Annamalai University, Tamil Nadu, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Blood Proteins / metabolism Cholesterol / blood Circadian Rhythm / drug effects*, physiology GABA Agonists / pharmacology Lactic Acid / blood Male Photoperiod Rats Rats, Wistar gamma-Aminobutyric Acid / analogs & derivatives, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Blood Proteins; 0/GABA Agonists; 3130-76-5/N-phthaloyl-4-aminobutyric acid; 50-21-5/Lactic Acid; 56-12-2/gamma-Aminobutyric Acid; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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