Document Detail

N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms.
MedLine Citation:
PMID:  24261470     Owner:  NLM     Status:  MEDLINE    
Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a twofold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of FBJ murine osteosarcoma viral oncogene and period1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-h delay). Here, we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances.
Fernando M Baidanoff; Santiago A Plano; Fabio Doctorovich; Sebastián A Suárez; Diego A Golombek; Juan J Chiesa
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-12-04
Journal Detail:
Title:  Journal of neurochemistry     Volume:  129     ISSN:  1471-4159     ISO Abbreviation:  J. Neurochem.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-03-24     Completed Date:  2014-05-15     Revised Date:  2014-05-19    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  60-71     Citation Subset:  IM    
Copyright Information:
© 2013 International Society for Neurochemistry.
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MeSH Terms
Circadian Rhythm / physiology*
Melatonin / analogs & derivatives*,  biosynthesis
Motor Activity / physiology
Nitroso Compounds
Photic Stimulation / methods*
Suprachiasmatic Nucleus / metabolism*
Grant Support
Reg. No./Substance:
0/N1-nitrosomelatonin; 0/Nitroso Compounds; JL5DK93RCL/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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