Document Detail


N-Myc down-regulated gene 1 mediates proliferation, invasion, and apoptosis of hepatocellular carcinoma cells.
MedLine Citation:
PMID:  18207320     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation or serum-independent growth of NIH3T3 cells. We used specific small interfering RNA (siRNA) oligos to suppress the expression of NDRG1 in human HCC (Hep3B and HepG2) cell lines, and found that this significantly reduced cell proliferation and invasion, and induced apoptosis. Additionally, NDRG1-specific siRNA inhibited the HepG2 xenograft growth in nude mice. These results are consistent with our earlier clinical observations that NDRG1 is associated with more aggressive tumor behavior, and suggest that NDRG1 may be a potential therapeutic target for HCC.
Authors:
Xinrui Yan; Mei-Sze Chua; Hongbo Sun; Samuel So
Publication Detail:
Type:  Journal Article     Date:  2008-01-22
Journal Detail:
Title:  Cancer letters     Volume:  262     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2011-05-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  133-42     Citation Subset:  IM    
Affiliation:
Asian Liver Center, Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, H3680, Stanford, CA 94305-5655, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Aspirin-associated intracerebral hemorrhage in a patient with CADASIL.
Next Document:  Assessment of heavy metal contamination and its mobilization from municipal solid waste open dumping...