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N-Alkylations of chitosan promoted with sodium hydrogen carbonate under aqueous conditions.
MedLine Citation:
PMID:  22197793     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chitosan was reacted with four alkyl halides, monobromoacetic acid, benzyl bromide, 2-bromoethanol, and monochloroacetic acid, in the presence of NaHCO(3) in water. Chemical structures, degrees of substitution, and degrees of polymerization of reaction products were studied by FT-IR, NMR, SEC-MALLS, and elementary analyses. All alkyl groups were introduced selectively into the C2-amine groups of chitosan, and the yields of the N-alkyl chitosans were >90% by this method. N-Carboxymethyl chitosan (N-CMCh) and N-benzyl chitosan (N-BnCh) with high degrees of substitution (DS) up to 200% and 164% of the C2-amine groups, respectively, were obtained; N,N-dicarboxymethyl and N,N-dibenzyl chitosans were obtained in high yields. Degrees of polymerization (DP) of N-CMCh decreased during the reaction. The greater the amount of monobromoacetic acid added, the lower the DP of N-CMCh.
Authors:
Y Kurita; A Isogai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-17
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  -     ISSN:  1879-0003     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
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