Document Detail

N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer.
MedLine Citation:
PMID:  21390146     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the possible association between meat intake, cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) risk.
METHODS: Patients with CRC were matched for gender and age to healthy controls. Meat intake and cigarette smoking were assessed using a specific frequency questionnaire. DNA was extracted from peripheral blood and the genotypes of the polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism. Five NAT2 alleles were studied (WT, M1, M2, M3 and M4) using specific digestion enzymes.
RESULTS: A total of 147 patients with colorectal cancer (76 women and 90 men with colon cancer) and 212 controls were studied. The mean age of the two groups was 62 years. More than half the subjects (59.8% in the case group and 51.9% in the control group) were NAT2 slow acetylators. The odds ratio for colorectal cancer was 1.38 (95% CI: 0.90-2.12) in slow acetylators. Although the number of women was small (n = 76 in the case group), the cancer risk was found to be lower in intermediate (W/Mx) acetylators [odds ratio (OR): 0.55, 95% confidence interval (95% CI): 0.29-1.02]. This difference was not observed in men (OR: 0.56, 95% CI: 0.16-2.00). Among NAT2 fast acetylators (W/W or W/Mx), meat consumption more than 3 times a week increased the risk of colorectal cancer (OR: 2.05, 95% CI: 1.01-4.16). In contrast, cigarette smoking increased the risk of CRC among slow acetylators (OR: 1.97, 95% CI: 1.02-3.79).
CONCLUSION: The risk of CRC was higher among fast acetylators who reported a higher meat intake. Slow NAT2 acetylation was associated with an increased risk of CRC.
Tiago Donizetti da Silva; Aledson Vitor Felipe; Jacqueline Miranda de Lima; Celina Tizuko Fujiyama Oshima; Nora Manoukian Forones
Related Documents :
11918576 - Oro-facial pain in the community: prevalence and associated impact.
3628856 - Long-term bladder symptomatology following radiotherapy for cervical carcinoma.
2031736 - Relationship between personality and premenstrual symptoms: a study in five general pra...
21438986 - Prevalence and the associated trigger factors of urinary incontinence among 5000 black ...
23676636 - Influence of patient perceptions and preferences for osteoporosis medication on adheren...
16099346 - Relationship between grip strength and hand bone mineral density in healthy adults.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-10     Completed Date:  2011-07-18     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  760-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arylamine N-Acetyltransferase / genetics*
Case-Control Studies
Colorectal Neoplasms / enzymology*,  genetics*
Genetic Association Studies
Genetic Predisposition to Disease
Middle Aged
Polymorphism, Genetic*
Risk Factors
Reg. No./Substance:
EC N-Acetyltransferase; EC protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells.
Next Document:  Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic.