Document Detail

N-Acetylserotonin prevents the hypotension induced by bacterial lipopolysaccharides in the rat.
MedLine Citation:
PMID:  7509747     Owner:  NLM     Status:  MEDLINE    
Nitric oxide is produced by the NO synthase, which catalyses the conversion of arginine to citrulline and NO using tetrahydrobiopterin as an essential cofactor. N-Acetylserotonin, an inhibitor of the tetrahydrobiopterin biosynthesis, given 30 min before bacterial lipopolysaccharide to anesthetized rats, inhibited both the decrease in blood pressure and the increase in nitrite plasma levels induced by lipopolysaccharide. Thus, during endotoxemia the availability of tetrahydrobiopterin appears to be essential for the activity of NO synthase.
P Klemm; J Ostrowski; T Morath; C Gruber; P A Martorana; R Henning
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  250     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-04-04     Completed Date:  1994-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  R9-10     Citation Subset:  IM    
Department of Pharmacology, Cassella AG, Frankfurt/Main, Germany.
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MeSH Terms
Amino Acid Oxidoreductases / metabolism
Blood Pressure / drug effects
Disease Models, Animal
Hypotension / chemically induced,  prevention & control*
Lipopolysaccharides / toxicity*
Nitric Oxide Synthase
Nitrites / blood
Rats, Sprague-Dawley
Serotonin / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Lipopolysaccharides; 0/Nitrites; 1210-83-9/N-acetylserotonin; 50-67-9/Serotonin; EC Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases

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