Document Detail


N-Acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model.
MedLine Citation:
PMID:  22676250     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: Intrauterine infection is associated with maternal immune activation (MIA) leading to preterm birth through upregulation of contractile associated proteins (CAPs). We hypothesized that N-acetylcysteine would decrease NFKB activation and CAP expression in a MIA model for preterm birth. Methods: Pregnant CD-1 mice were given intrauterine LPS or saline on day 15/20. They received NAC or saline prior to injection and were monitored until delivery. The rate of preterm birth in the control, LPS, and LPS + NAC animals was determined. In another group, animals were sacrificed 6 hours after treatment and myometrium was collected. COX-2, connexin 43, and oxytocin receptor expression was determined. Results: LPS adminstration resulted in preterm birth and this effect was attenuated by NAC. LPS increased COX-2, connexin 43, and oxytocin receptor expression. NAC significantly decreased COX-2 expression. LPS increased NFKB activation; this was attenuated by NAC. Conclusion: NAC may be beneficial in prevention of MIA-related preterm birth through attenuation of NFKB activation and COX-2 upregulation.
Authors:
Eugene Y Chang; Jingmei Zhang; Scott Sullivan; Roger Newman; Inderjit Singh
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-7
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Medical University of South Carolina.
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