| N-Acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model. | |
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MedLine Citation:
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PMID: 22676250 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective: Intrauterine infection is associated with maternal immune activation (MIA) leading to preterm birth through upregulation of contractile associated proteins (CAPs). We hypothesized that N-acetylcysteine would decrease NFKB activation and CAP expression in a MIA model for preterm birth. Methods: Pregnant CD-1 mice were given intrauterine LPS or saline on day 15/20. They received NAC or saline prior to injection and were monitored until delivery. The rate of preterm birth in the control, LPS, and LPS + NAC animals was determined. In another group, animals were sacrificed 6 hours after treatment and myometrium was collected. COX-2, connexin 43, and oxytocin receptor expression was determined. Results: LPS adminstration resulted in preterm birth and this effect was attenuated by NAC. LPS increased COX-2, connexin 43, and oxytocin receptor expression. NAC significantly decreased COX-2 expression. LPS increased NFKB activation; this was attenuated by NAC. Conclusion: NAC may be beneficial in prevention of MIA-related preterm birth through attenuation of NFKB activation and COX-2 upregulation. |
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Authors:
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Eugene Y Chang; Jingmei Zhang; Scott Sullivan; Roger Newman; Inderjit Singh |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-7 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Obstetrics and Gynecology, Medical University of South Carolina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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