Document Detail

N-acetylcysteine does not prevent renal dysfunction after off-pump coronary artery bypass surgery.
MedLine Citation:
PMID:  20299984     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Coronary artery bypass graft surgery in high-risk patients may be associated with postoperative renal dysfunction. N-Acetylcysteine is a powerful antioxidant and has been used to prevent contrast-induced renal dysfunction. The efficacy of N-acetylcysteine in preventing postoperative renal dysfunction following off-pump coronary artery bypass graft surgery was studied.
METHODS: A prospective, randomized, controlled study was conducted in patients undergoing off-pump coronary artery bypass graft. The study group (37 patients) received N-acetylcysteine in the perioperative period, whereas the control group (37 patients) did not. The data obtained were analysed using the independent sample t-test (Student's t-test) and χ-test.
RESULTS: There was no significant difference in the incidence of renal dysfunction between the two groups. Three patients (8.6%) in the N-acetylcysteine group and four (11.4%) in the control group developed renal dysfunction (P value was 1.00).
CONCLUSION: N-Acetylcysteine does not have any beneficial effect on renal function in high-risk patients undergoing off-pump coronary artery bypass graft.
Apoorva Prasad; Sanjaykumar Banakal; Kanchi Muralidhar
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  27     ISSN:  1365-2346     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-08     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  973-7     Citation Subset:  IM    
Department of Anaesthesiology, Narayana Hrudayalaya Institute of Medical Sciences, Bommasandra Industrial Area, Bangalore, India.
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MeSH Terms
Acetylcysteine / pharmacology*
Coronary Artery Bypass, Off-Pump / adverse effects*,  methods
Follow-Up Studies
Free Radical Scavengers / pharmacology*
Middle Aged
Pilot Projects
Prospective Studies
Renal Insufficiency / etiology,  prevention & control*
Risk Factors
Reg. No./Substance:
0/Free Radical Scavengers; 616-91-1/Acetylcysteine

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