Document Detail

N-3 polyunsaturated fatty acid diet therapy for patients with inflammatory bowel disease.
MedLine Citation:
PMID:  20222122     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: N-3 polyunsaturated fatty acids (PUFA) are considered important pharmaconutrients for modulating mucosal immunity and therapeutic responses in patients with inflammatory bowel disease (IBD). We investigated the influence of diet therapy involving the use of an "n-3 PUFA food exchange table" (n-3DP) on the fatty acid composition of the erythrocyte membranes of IBD patients and its remission-maintaining effects.
METHODS: We analyzed the fatty acid composition of the erythrocyte membrane before and after n-3DP intervention in 20 initial-onset IBD patients who had not undergone any dietary intervention. We then analyzed it again and evaluated disease activity after 12-18 months intervention in 230 IBD patients (168 ulcerative colitis, 62 Crohn's disease; follow-up group) in whom n-3DP was introduced after remission had been achieved. The follow-up group was divided into remission and relapse groups.
RESULTS: In the 20 initial-onset patients, the mean n-3/n-6 ratio significantly increased after intervention (0.41 ± 0.16 versus 0.70 ± 0.20; P < 0.001). In the follow-up group the ratio in the remission group (n = 145) was significantly higher than that in the relapse group (n = 85) (0.65 ± 0.28 versus 0.53 ± 0.18; P < 0.001). The ratio significantly decreased in those who suffered a relapse after the beginning of treatment (P < 0.01).
CONCLUSIONS: N-3DP significantly increased the erythrocyte membrane n-3/n-6 ratio in IBD patients, and this ratio was significantly higher in the remission group, suggesting that n-3DP alters the fatty acid composition of the cell membrane and influences clinical activity in IBD patients.
Kan Uchiyama; Makoto Nakamura; Shunichi Odahara; Shigeo Koido; Kiyohiko Katahira; Hiromi Shiraishi; Toshifumi Ohkusa; Kiyotaka Fujise; Hisao Tajiri
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Inflammatory bowel diseases     Volume:  16     ISSN:  1536-4844     ISO Abbreviation:  Inflamm. Bowel Dis.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508162     Medline TA:  Inflamm Bowel Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1696-707     Citation Subset:  IM    
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Kashiwa Hospital, Chiba, Japan.
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MeSH Terms
Colitis, Ulcerative / blood,  diet therapy*
Crohn Disease / blood,  diet therapy*
Erythrocyte Membrane / metabolism
Fatty Acids, Omega-3 / administration & dosage*,  metabolism
Follow-Up Studies
Intervention Studies
Reg. No./Substance:
0/Fatty Acids, Omega-3

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