Document Detail


Myxotyrosides A and B, Unusual rhamnosides from Myxococcus sp.
MedLine Citation:
PMID:  19113894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myxobacteria are gliding bacteria of the delta-subdivision of the Proteobacteria and known for their unique biosynthetic capabilities. Two examples of a new class of metabolites, myxotyrosides A (1) and B (2), were isolated from a Myxococcus sp. The myxotyrosides have a tyrosine-derived core structure glycosylated with rhamnose and acylated with unusual fatty acids such as (Z)-15-methyl-2-hexadecenoic and (Z)-2-hexadecenoic acid. The fatty acid profile of the investigated Myxococcus sp. (strain 131) is that of a typical myxobacterium with a high similarity to those described for M. fulvus and M. xanthus, with significant concentrations of neither 15-methyl-2-hexadecenoic acid nor 2-hexadecenoic acid being detected.
Authors:
Birgit Ohlendorf; Wolfram Lorenzen; Stefan Kehraus; Anja Krick; Helge B Bode; Gabriele M König
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of natural products     Volume:  72     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  82-6     Citation Subset:  IM    
Affiliation:
Institute of Pharmaceutical Biology, UniVersity of Bonn, Nussallee 6, D-53115 Bonn, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / chemistry,  isolation & purification*,  pharmacology
Bacillus megaterium / drug effects
Chlorella / drug effects
Drug Screening Assays, Antitumor
Escherichia coli / drug effects
Eurotium / drug effects
Fatty Acids / genetics
Gas Chromatography-Mass Spectrometry
Glycolipids / chemistry,  isolation & purification*,  pharmacology
Microbial Sensitivity Tests
Molecular Structure
Myxococcus / chemistry*
Plasmodium falciparum / drug effects
Pseudomonas putida / drug effects
Quorum Sensing
Rhamnose / analogs & derivatives*,  chemistry,  isolation & purification*,  pharmacology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Fatty Acids; 0/Glycolipids; 0/myxotyroside A; 0/myxotyroside B; 10485-94-6/Rhamnose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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