| Myxotyrosides A and B, Unusual rhamnosides from Myxococcus sp. | |
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MedLine Citation:
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PMID: 19113894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myxobacteria are gliding bacteria of the delta-subdivision of the Proteobacteria and known for their unique biosynthetic capabilities. Two examples of a new class of metabolites, myxotyrosides A (1) and B (2), were isolated from a Myxococcus sp. The myxotyrosides have a tyrosine-derived core structure glycosylated with rhamnose and acylated with unusual fatty acids such as (Z)-15-methyl-2-hexadecenoic and (Z)-2-hexadecenoic acid. The fatty acid profile of the investigated Myxococcus sp. (strain 131) is that of a typical myxobacterium with a high similarity to those described for M. fulvus and M. xanthus, with significant concentrations of neither 15-methyl-2-hexadecenoic acid nor 2-hexadecenoic acid being detected. |
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Authors:
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Birgit Ohlendorf; Wolfram Lorenzen; Stefan Kehraus; Anja Krick; Helge B Bode; Gabriele M König |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of natural products Volume: 72 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-27 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 82-6 Citation Subset: IM |
Affiliation:
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Institute of Pharmaceutical Biology, UniVersity of Bonn, Nussallee 6, D-53115 Bonn, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemistry, isolation & purification*, pharmacology Bacillus megaterium / drug effects Chlorella / drug effects Drug Screening Assays, Antitumor Escherichia coli / drug effects Eurotium / drug effects Fatty Acids / genetics Gas Chromatography-Mass Spectrometry Glycolipids / chemistry, isolation & purification*, pharmacology Microbial Sensitivity Tests Molecular Structure Myxococcus / chemistry* Plasmodium falciparum / drug effects Pseudomonas putida / drug effects Quorum Sensing Rhamnose / analogs & derivatives*, chemistry, isolation & purification*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Fatty Acids; 0/Glycolipids; 0/myxotyroside A; 0/myxotyroside B; 10485-94-6/Rhamnose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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