|Myxoid fibroadenoma and allied conditions (myxomatosis) of the breast. A heritable disorder with special associations including cardiac and cutaneous myxomas.|
|PMID: 2069209 Owner: NLM Status: MEDLINE|
|Among 145 patients with the complex of myxomas, spotty pigmentation, endocrine overactivity, and psammomatous melanotic schwannomas, 31 (21%) had mammary lesions. The ages of these 26 females and five males ranged from 6 to 64 years (mean, 30 years). Five patients had breast symptoms. In 21 (81%) of the females, benign mesenchymal lesion(s) were detected pathologically. These were characterized by accumulations of large amounts of ground substance in the lobules that alterated the stroma to a very loose and myxoid tissue. The change involved single lobules (lobular myxoid change), small groups of lobules (nodular myxoid change), and large aggregates of lobules (myxoid fibroadenoma); the interlobular stroma was affected to a lesser degree. The lesions were multicentric and bilateral in eight patients (38%). Because the myxoid breast lesions were familial, were frequent findings in the complex, and were similar histologically to the cardiac and cutaneous myxomas in the complex, they undoubtedly are a component and a pathologic marker of the complex. They were the presenting feature of the complex in six patients (19%). Therefore, discovery of the myxoid breast lesions on pathologic examination should raise suspicion of the complex, and affected patients (and their primary relatives) should be evaluated accordingly.|
|J A Carney; B C Toorkey|
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|Type: Journal Article|
|Title: The American journal of surgical pathology Volume: 15 ISSN: 0147-5185 ISO Abbreviation: Am. J. Surg. Pathol. Publication Date: 1991 Aug|
|Created Date: 1991-08-15 Completed Date: 1991-08-15 Revised Date: 2004-11-17|
Medline Journal Info:
|Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: UNITED STATES|
|Languages: eng Pagination: 713-21 Citation Subset: IM|
|Section of Surgical Pathology, Mayo Clinic, Rochester, MN 55905.|
|APA/MLA Format Download EndNote Download BibTex|
Breast Neoplasms / pathology*, surgery
Cushing Syndrome / pathology
Heart Neoplasms / pathology*
Lentigo / pathology
Melanoma / pathology
Myxoma / pathology*
Neoplasms, Multiple Primary / pathology*
Neuroma / pathology
Skin Neoplasms / pathology*
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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