Document Detail

Myxoid fibroadenoma and allied conditions (myxomatosis) of the breast. A heritable disorder with special associations including cardiac and cutaneous myxomas.
MedLine Citation:
PMID:  2069209     Owner:  NLM     Status:  MEDLINE    
Among 145 patients with the complex of myxomas, spotty pigmentation, endocrine overactivity, and psammomatous melanotic schwannomas, 31 (21%) had mammary lesions. The ages of these 26 females and five males ranged from 6 to 64 years (mean, 30 years). Five patients had breast symptoms. In 21 (81%) of the females, benign mesenchymal lesion(s) were detected pathologically. These were characterized by accumulations of large amounts of ground substance in the lobules that alterated the stroma to a very loose and myxoid tissue. The change involved single lobules (lobular myxoid change), small groups of lobules (nodular myxoid change), and large aggregates of lobules (myxoid fibroadenoma); the interlobular stroma was affected to a lesser degree. The lesions were multicentric and bilateral in eight patients (38%). Because the myxoid breast lesions were familial, were frequent findings in the complex, and were similar histologically to the cardiac and cutaneous myxomas in the complex, they undoubtedly are a component and a pathologic marker of the complex. They were the presenting feature of the complex in six patients (19%). Therefore, discovery of the myxoid breast lesions on pathologic examination should raise suspicion of the complex, and affected patients (and their primary relatives) should be evaluated accordingly.
J A Carney; B C Toorkey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  15     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-15     Completed Date:  1991-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  713-21     Citation Subset:  IM    
Section of Surgical Pathology, Mayo Clinic, Rochester, MN 55905.
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MeSH Terms
Adenofibroma / pathology*,  surgery
Breast Neoplasms / pathology*,  surgery
Child, Preschool
Cushing Syndrome / pathology
Family Health
Heart Neoplasms / pathology*
Lentigo / pathology
Melanoma / pathology
Middle Aged
Myxoma / pathology*
Neoplasms, Multiple Primary / pathology*
Neuroma / pathology
Skin Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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