Document Detail


Myxoid change of the myometrium and cervical stroma: description of a hitherto unreported non-neoplastic phenomenon with discussion of myxoid uterine lesions.
MedLine Citation:
PMID:  20567149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report 3 cases of a hitherto undescribed phenomenon in women aged 46 to 49 in which there was replacement of the myometrium or cervical stroma by an accumulation of hypocellular myxoid stromal material containing bland spindle-shaped cells and small blood vessels. In all cases, this change was conspicuous, and in 2 it was multifocal and widespread, resulting in consideration of an infiltrative myxoid mesenchymal neoplasm. Immunohistochemistry revealed a characteristic immunophenotype with diffuse strong positivity with CD34 and CD10 but no immunoreactivity with the smooth muscle markers desmin, alpha-smooth muscle actin, and h-caldesmon. In comparison, 3 cases of uterine myxoid leiomyoma were positive with smooth muscle markers and negative with CD34 and CD10. We believe the lesion we describe to be an unusual pseudoneoplastic, possibly degenerative, phenomenon. The patients past medical histories were unremarkable, with no history of connective tissue disease (myometrial myxoidosis has rarely been described in association with lupus erytematosus) or Carney's syndrome. Two patients had been prescribed local or systemic progestogens, raising the possibility of an association with these compounds. Pathologists should be aware of this unusual pseudoneoplastic phenomenon to avoid a misdiagnosis of a neoplastic lesion.
Authors:
W Glenn McCluggage; Robert H Young
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  29     ISSN:  1538-7151     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-7     Citation Subset:  IM    
Affiliation:
Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland. glenn.mccluggage@belfasttrust.hscni.net
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Activin Receptors, Type II / metabolism
Antigens, CD34 / metabolism
Calmodulin-Binding Proteins / metabolism
Desmin / metabolism
Female
Humans
Immunohistochemistry
Middle Aged
Neprilysin / metabolism
Receptors, Estrogen / metabolism
Retrospective Studies
Stromal Cells / metabolism,  pathology*
Uterine Neoplasms / metabolism,  pathology*
Chemical
Reg. No./Substance:
0/Actins; 0/Antigens, CD34; 0/Calmodulin-Binding Proteins; 0/Desmin; 0/Receptors, Estrogen; EC 2.7.11.30/ACVRL1 protein, human; EC 2.7.11.30/Activin Receptors, Type II; EC 3.4.24.11/Neprilysin

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