| Myxobacteria, producers of novel bioactive substances. | |
| | |
MedLine Citation:
|
PMID: 11780785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Myxobacteria are soil bacteria that move by gliding and have an astonishing life cycle culminating in fruiting body formation. In a research program at the Gesellshaft für Biotechnologische Forschung over the past 25 years the organisms have been shown to be a rich source of potentially useful secondary metabolites. So far about 80 different basic compounds and 450 structural variants have been characterized. Many of those compounds were new. It is particularly remarkable that myxobacteria specialize in mechanisms of action that are very rare with other producers. Thus 20 new electron transport inhibitors, 10 substances that act on the cytoskeleton, four inhibitors of nucleic acid polymerases, and one inhibitor of fungal acetyl-CoA carboxylase, a novel mechanism of action, have been found. |
| | |
Authors:
|
H Reichenbach |
Related Documents
:
|
9145285 - Photocross-linking of nucleic acids to associated proteins. 9868925 - Larval tolerance in the drosophila melanogaster species complex toward the two toxic ac... 21045545 - Biophysical studies of the nucleic acid chaperone properties of the hiv-1 nucleocapsid ... 8633675 - Selective photosensitizer distribution in vulvar condyloma acuminatum after topical app... 9810695 - Triterpenes from the spores of ganoderma lucidum and their inhibitory activity against ... 15354385 - Mthfr c677t polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patie... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Journal of industrial microbiology & biotechnology Volume: 27 ISSN: 1367-5435 ISO Abbreviation: J. Ind. Microbiol. Biotechnol. Publication Date: 2001 Sep |
Date Detail:
|
Created Date: 2002-01-08 Completed Date: 2002-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9705544 Medline TA: J Ind Microbiol Biotechnol Country: England |
Other Details:
|
Languages: eng Pagination: 149-56 Citation Subset: IM |
Affiliation:
|
GBF, Gesellschaft für Biotechnologische Forschung, Abteilung Naturstoffbiologie, Braunschweig, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Actins
/
metabolism Bacterial Proteins / biosynthesis*, pharmacology DNA-Directed RNA Polymerases / antagonists & inhibitors Deltaproteobacteria / metabolism* Electron Transport / drug effects Soil Microbiology Tubulin / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Actins; 0/Bacterial Proteins; 0/Tubulin; EC 2.7.7.6/DNA-Directed RNA Polymerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Simocyclinones: diversity of metabolites is dependent on fermentation conditions.
Next Document: Chemical diversity in lipopeptide antifungal antibiotics.