Document Detail

Myxedema coma.
MedLine Citation:
PMID:  17712058     Owner:  NLM     Status:  MEDLINE    
Untreated or unrecognized hypothyroidism may progress to severe decompensated hypothyroidism or myxedema coma. Relatively few cases are reported in the literature since the first case was apparently reported from the St. Thomas Hospital in London in 1879. The paucity of cases may be due to either underreporting or improvement in the diagnosis and treatment of uncomplicated hypothyroidism. However, despite the ready availability of sensitive thyrotropin assays, the recognition and treatment of myxedema coma remains a challenge. Although thyroid hormone treatment is highly effective when combined with ventilatory and hemodynamic support in the intensive care unit setting, controversies abound on the optimal and most effective choice of thyroid hormone preparation: thyroxine and triiodothyronine and in what amount. Accumulated evidence now shows that proper use of either thyroxine alone or in combination with triiodothyronine may be effective therapy.
Maxwell P Kwaku; Kenneth D Burman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of intensive care medicine     Volume:  22     ISSN:  0885-0666     ISO Abbreviation:  J Intensive Care Med     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-08-22     Completed Date:  2007-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610344     Medline TA:  J Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  224-31     Citation Subset:  IM    
Endocrine Section, Washington Hospital Center, Washington, DC 20010-2975, USA.
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MeSH Terms
Coma / etiology*,  physiopathology,  therapy
Hypothyroidism / complications*,  therapy
Myxedema / diagnosis*,  etiology,  physiopathology,  therapy

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