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A Mystery Wrapped in an Enigma: Matrigel Enhancement of Mammary Cell Growth and Morphogenesis.
MedLine Citation:
PMID:  22581302     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The analysis of normal mammary morphogenesis is facilitated by the use of mammary fat pad transplantation. The recent experiments on analysis of normal mammary epithelial stem cell activity rely heavily on this technique. In this review, we discuss the known and unknown attributes of using Matrigel in the injection of the mammary epithelial cell suspension. Matrigel greatly increases the "take" frequency of the injected cell suspension; however, there is some uncertainty regarding the interpretation of some of the results. After consideration of these issues, our conclusion is that Matrigel is important in order to obtain rigorous and reproducible results.
Authors:
Michael T Lewis; John D Landua; Homer C Adams; Daniel Medina
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-13
Journal Detail:
Title:  Journal of mammary gland biology and neoplasia     Volume:  -     ISSN:  1573-7039     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9601804     Medline TA:  J Mammary Gland Biol Neoplasia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
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