Document Detail


Myotoxicity of single and repeated injections of mepivacaine (Carbocaine) in the rat.
MedLine Citation:
PMID:  7189366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Young rats received single or repeated injections of 2% mepivacaine (Carbocaine) into the tibialis anterior or extensor digitorum longus muscles. Repeated injections consisted of six injections of the anesthetic (100 microliter per injection into the tibialis anterior) on three different schedules, at intervals of 2 1/2 hours, 24 hours, or 4 days. The muscles that had been given injections were examined histologically for evidence of myotoxicity at 0 to 7 and 20 days after the last injection. Single injection studies showed that mepivacaine is a myotoxic drug, producing a lesion which ultimately results in the degeneration and subsequent regeneration of large amounts of muscle. A similar picture was seen with repeated injections except that greater tissue destruction was noted. Long-term studies following a single injection of mepivacaine showed restoration of the original muscle structure whereas after repeated injections some muscles showed persisting foci of increased intersitial connective tissue. This study shows that in rats 2% mepivacaine is a myotoxic drug, but that the damage it produces is to a large extent restored by the regeneration of new muscle fibers.
Authors:
M D Basson; B M Carlson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  59     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-06-27     Completed Date:  1980-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  275-82     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Injections, Intramuscular
Male
Mepivacaine / administration & dosage,  toxicity*
Muscles / drug effects,  pathology,  physiology*
Rats / physiology*
Regeneration / drug effects
Chemical
Reg. No./Substance:
96-88-8/Mepivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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